(click on title to reveal more information)
Anogenital Tract clinic database
UCT investigator: Lynette Denny/Nomonde Mbatani
Email address: lynette.denny@uct.ac.za /nomonde.mbatani@uct.ac.za
Closed
Does enhanced recovery after surgery for radical cystectomy improve outcomes?
Contact UCT investigator: Justin Howlett
Email address: howlettjustin@gmail.com
Closed
Medical image synthesis - Development and validation of MRI-based synthetic CT: applications in treating bone pathologies
Contact UCT investigator: Tinashe Mutsvangwa
Email address: tinashe.mutsvangwa@uct.ac.za
International study on treatment and prognosis of pathological fractures
Contact UCT investigator: Thomas Hilton
Email address: tlhilton@hotmail.com
SA sarcoma registry
Contact UCT investigator: Thomas Hilton
Email address: tlhilton@hotmail.com
Closed
Paediatric brain tumours in South Africa
Contact UCT investigator: Anthony Figaji
Email address: anthony.figaji@uct.ac.za
Medulloblastoma
Contact UCT investigator: Jeanette Parkes
Email address: jeanette.parkes@uct.ac.za
Development of SNAP-tag and CLIP-tag based antibody fusion proteins targeting Glioblastoma
Contact UCT investigator: Sanele Cingo /Stefan Barth
Email address: cngsip004@myuct.ac.za / stefan.barth@uct.ac.za
Investigating the anti-cancer activity of novel phenothiazines in glioblastoma
Contact UCT investigator: Sharon Prince/Anwar Jardine
Email address: sharon.prince@uct.ac.za
Exploitation of a novel phenothiazine derivative for its anti-cancer activities in malignant glioblastoma
Contact UCT investigator: Sharon Prince/Anwar Jardine
Email address: sharon.prince@uct.ac.za / anwar.jardine@uct.ac.za
Closed
Normalization of tumour metabolism to modulate radiation response
Contact UCT investigator: Alistair Hunter
Email address: alistair.hunter@uct.ac.za
Identification and investigation of factors modulating tumour resistance to cytotoxic challenge in the context of mitochondrially-determined cell death
Contact UCT investigator: Alistair Hunter / Michelle Parker
Email address: alistair.hunter@uct.ac.za / michelle.parker@uct.ac.za
A correlation between shoulder pain and dysfunction and inflammatory cytokine genotyping in breast cancer patients
Contact UCT investigator: Delva Shamley
Email address: delva.shamley@uct.ac.za
Development and implementation of an integrated lymphoedema and upper limb rehabilitation management pathway following treatment for breast cancer
Contact UCT investigator: Delva Shamley
Email address: delva.shamley@uct.ac.za
Opioid prescription post-surgery for breast cancer and the development of chronic pain
Contact UCT investigator: Delva Shamley
Email address: delva.shamley@uct.ac.za
Pain lateralisation in breast cancer patients: a fMRI and genotyping study
Contact UCT investigator: Delva Shamley
Email address: delva.shamley@uct.ac.za
Prevalence of upper limb morbidity following adjuvant therapy in breast cancer survivors in SA
Contact UCT investigator: Delva Shamley
Email address: delva.shamley@uct.ac.za
Extended Cost Effectiveness of Interventions for Early Detection & Treatment of Breast Cancer: A Case Study of South Africa and Uganda
Contact UCT investigator: Edina Sinanovic
Email address: edina.sinanovic@uct.ac.za
Improving timely diagnosis of symptomatic breast and cervical cancer in Sub-Saharan Africa
Contact UCT investigator: Jennifer Moodley
Email address: jennifer.moodley@uct.ac.za
Primary health care providers knowledge and management of symptoms suggestive of breast cancer
Contact UCT investigator: Jennifer Moodley
Email address: jennifer.moodley@uct.ac.za
Advancing Early Diagnosis of Breast Cancer in Southern Africa - the African aWAreness of CANcer and Early Diagnosis (AWACAN-ED) project
Contact UCT investigator: Jennifer Moodley
Email address: jennifer.moodley@uct.ac.za
Clinical Trial of the Aceso Dual-Modality System for the Early Detection of Breast Cancer: A Joint Project Between Number Two Military Hospital In Wynberg and CapeRay Medical (Pty) Ltd
Contact UCT investigator: Kamila Padia / Kit Vaughan
Email address: kamila.padia@uct.ac.za / Kit.vaughan@uct.ac.za
Human Dendritic Cell Vaccination (DCV) Against Breast cancer: A Single Blind randomized trial
Contact UCT investigator: Keertan Dheda / David Anderson
Email address: keertan.dheda@uct.ac.za / david.anderson@uct.ac.za
Rational Design of Glycoenzyme inhibitors and their Targeted Delivery for Blocking Apoptotic Metastatic Pathways in Breast Cancer Tumours
Contact UCT investigator: Kevin Naidoo
Email address: kevin.naidoo@uct.ac.za
A Proof of Principle Application of the GlycoEnzyme Gene Biomarker for Early Detection of Breast Cancer in a South African Population
Contact UCT investigator: Kevin Naidoo
Email address: kevin.naidoo@uct.ac.za
An exploration of symptom burden among breast and gynaecological cancer patients accessing care at University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria
Contact UCT investigator: Liz Gwyther
Email address: liz.gwyther@uct.ac.za
Radio Guided Occult Lesion Localisation as a diagnostic and therapeutic procedure: Clinical review at a single South African institution
Contact UCT investigator: Lydia Cairncross
Email address: lydia.cairncross@uct.ac.za
Antibody engineering to enhance antigen affinity, internalization and pharmacokinetics of tumor-targeting fusion proteins
Contact UCT investigator: Maryam Karaan /Stefan Barth
Email address: krnmar009@myuct.ac.za / stefan.barth@uct.ac.za
Establishment of technology platforms in support of future precision medicine applications in South Africa
Contact UCT investigator: Musa Mhlanga / Stefan Barth
Email address: musa.mhlanga@uct.ac.za / stefan.barth@uct.ac.za
Development of SNAP tag-based antibody fusion proteins for multiplex Immunofluorescence (mIF) and immunotherapy of Triple Negative Breast Cancer (TNBC)
Contact UCT investigator: Natasha Hardcastle /Stefan Barth
Email address: natasha.hardcastle@uct.ac.za / stefan.barth@uct.ac.za
Development of CSPG4-targeting MAP tau-based human cytolytic fusion proteins and novel auristatin F-containing immunoconjugates for the treatment of triple-negative breast cancer
Contact UCT investigator: Neelakshi Mungra /Stefan Barth
Email address: mngnee002@myuct.ac.za / stefan.barth@uct.ac.za
Lynch Syndrome
Contact UCT investigator: Paul Goldberg
Email address: paul.goldberg@uct.ac.za
Development of CSPG4-targeting human cytolytic fusion proteins based on Angiogenin variants for the treatment of triple-negative breast cancer
Contact UCT investigator: Sandra Jordaan/Stefan Barth
Email address: sandrajordaanibms@gmail.com / stefan.barth@uct.ac.za
Identification of novel drug targets for treating breast cancer
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
Repurposing of commercial drugs that target the oncogenic TBX2 and TBX3 for anti-cancer activity
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
Development of novel immunodiagnostic techniques using SNAP-tag based antibody fusion proteins as imaging tools for the validation of Triple Negative Breast Cancer (TNBC).
Contact UCT investigator: Siyabulela Magugu /Stefan Barth
Email address: mggsiy003@myuct.ac.za / stefan.barth@uct.ac.za
A randomized open label phase III study of single agent pembrolizumab versus single agent chemotherapy per physician’s choice for metastatic triple negative breast cancer (mTNBC)
Contact UCT investigator: Zainab Mohamed
Email address: zainab.mohamed@uct.ac.za
The role and regulation of TBX2/TBX3 in breast cancer
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
The c-Myc/Akt/TBX3/Hsc70/nucleolin signaling axis in breast cancer
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
Chromomycin A5 targets the oncogenic TBX2 as a new strategy to treat breast cancer
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
Closed
B-cell lymphoma at the Red Cross Children’s Hospital in the HIV era
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
Factors Associated with Childhood Tumours (FACT) study
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
Low grade gliomas treated at the UCT Academic Hospital Complex 2001-2013
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
National incidence and treatment outcomes of paediatric acute lymphoblastic leukaemia in South Africa over a five year period
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
Prevalence, incidence and risk factors, survival and prognosis for HIV-infected children developing cancer
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
Race as a prognostic determinant in children with acute lymphoblastic leukaemia
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
Adapted Treatment Regimens for Hepatoblastoma and AML
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
HIV and childhood malignancy in South Africa
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
Childhood histiocytosis in South African paediatric oncology units
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
Clinical outcome of children with Hodgkin Lymphoma after chemotherapy alone – the Red Cross Children’s Hospital experience
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
Epidemiology of paediatric Cancer in the RCCH/GSH/UCT complex
Contact: Alan Davidson / Jeannette Parkes / Komala Pillay
Email address: alan.davidson@uct.ac.za / jeannette.parkes@uct.ac.za / komala.pillay@uct.ac.za
Paediatric brain tumours in South Africa
Contact UCT investigator: Anthony Figaji
Email address: anthony.figaji@uct.ac.za
Hodgkin lymphoma in South African children and adolescents from 2000-2010: A first report by the South African Children’s Cancer Study Group (SACCSG)
Contact UCT investigator: Marc Hendricks
Email address: marc.hendricks@uct.ac.za
Use of palliative chemotherapy in South Africa: National survey of paediatric oncologists and experience in a single unit
Contact UCT investigator: Michelle Meiring
Email address: michelle.meiring@uct.ac.za
Palliative & supportive care needs of children with cancer from the family’s viewpoint: Can we do better?
Contact UCT investigator: Michelle Meiring
Email address: michelle.meiring@uct.ac.za
Closed
Advancing early diagnosis of colorectal cancer in Southern Africa - the African aWAreness of CANcer and Early Diagnosis (AWACAN-ED) project
Contact UCT investigator: Jennifer Moodley
Email address: jennifer.moodley@uct.ac.za
Dysregulation of CT antigen expression in HNPCC and microbially-associated colorectal cancers
Contact UCT investigator: Jonathan Blackburn
Email address: jonathan.blackburn@uct.ac.za
Pharmacoproteomic and pharmacogenomic profiling of stage II and III primary colorectal carcinoma tissue
Contact UCT investigator: Jonathan Blackburn
Email address: jonathan.blackburn@uct.ac.za
Worm power: Can helminths modify the development of colorectal cancer?
Contact UCT investigator: Katherine Smith
Email address: katie.smith@uct.ac.za
Establishment of technology platforms in support of future precision medicine applications in South Africa
Contact UCT investigator: Musa Mhlanga / Stefan Barth
Email address: musa.mhlanga@uct.ac.za / stefan.barth@uct.ac.za
Lynch Syndrome
Contact UCT investigator: Paul Goldberg
Email address: paul.goldberg@uct.ac.za
A genetic registry for colorectal cancers
Contact UCT investigator: Raj Ramesar
Email address: raj.ramesar@uct.ac.za
Cancer pathways analysis in individuals with Lynch Syndrome
Contact UCT investigator: Raj Ramesar
Email address: raj.ramesar@uct.ac.za
Can an Enhanced Recovery After Surgery Program Improve patient outcomes after elective colorectal cancer surgery ?
Contact UCT investigator: Ravi Oodit
Email address: ravioodit@gmail.com
Closed
A biochemical analysis of mucus and mucins in pseudomyxoma peritonei (cancer of the appendix)
Contact UCT investigator: Anwar Mall
Email address: anwar.mall@uct.ac.za
Characterization of gastrointestinal stromal tumour mutations in a South African cohort
Contact UCT investigator: Barbara Robertson
Email address: barbara.robertson@uct.ac.za
A phase 3 randomized double-blind clinical study of pembrolizumab (MK-3475) plus chemotherapy as first-line treatment in participants with HER-2 negative, previously untreated, unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma (KEYNOTE-859)
Contact UCT investigator: Barbara Robertson
Email address: barbara.robertson@uct.ac.za
Closed
Salivary gland rescue to overcome radiotherapy-induced xerostomia
Contact UCT investigator: Alistair Hunter
Email address: alistair.hunter@uct.ac.za
Closed
Normalization of tumour metabolism to modulate radiation response
Contact UCT investigator: Alistair Hunter
Email address: alistair.hunter@uct.ac.za
Role of Seminal fluid on cervical cancer development
Contact UCT investigator: Arieh Katz
Email address: arieh.katz@uct.ac.za
Effects of KPNB1 small molecule inhibitors on seminal fluid-regulation of proinflammatory and angiogenic genes in cervical cancer cells
Contact UCT investigator: Arieh Katz
Email address: arieh.katz@uct.ac.za
Effect of surfactant protein A and vimentin on HPV16 pseudovirus infection
Contact UCT investigator: Arieh Katz
Email address: arieh.katz@uct.ac.za
Identify genomic changes in rapidly progressing cervical cancers to be used as biomarkers
Contact UCT investigator: Arieh Katz
Email address: arieh.katz@uct.ac.za
The Genetics and management of cervical cancer in Zimbabwe: focusing on pharmacogenetics
Contact UCT investigator: Collet Dandara
Email address: collet.dandara@uct.ac.za
Investigation of the impact of the vaginal microbiota on human papillomavirus infections
Contact UCT investigator: Anna-Lise Williamson
Email address: anna-lise.williamson@uct.ac.za
A study of the feasibility of introducing a Swedish HPV test for the management of cervical disease in the Eastern Cape
Contact UCT investigator: Anna-Lise Williamson
Email address: anna-lise.williamson@uct.ac.za
Evolutionary relationships among HPV subtypes in the Eastern Cape
Contact UCT investigator: Anna-Lise Williamson
Email address: anna-lise.williamson@uct.ac.za
HPV and cervical screening in the Eastern Cape (joint project UCT/WSU and Uppsala University)
Contact UCT investigator: Anna-Lise Williamson
Email address: anna-lise.williamson@uct.ac.za
Identification and characterization of HPV entry receptors as potential drug targets
Contact UCT investigator: Georgia Schäfer
Email address: georgia.schafer@uct.ac.za
The role of cell surface vimentin for HPV16 infection
Contact UCT investigator: Georgia Schäfer
Email address: georgia.schafer@uct.ac.za
The role of surfactant proteins in immunity to HPV16 infection
Contact UCT investigator: Georgia Schäfer
Email address: georgia.schafer@uct.ac.za
Molecular Markers Predicting CIN3 with high risk to Progress to Cervical Cancer
Contact UCT investigator: Hue-Tsi Wu
Email address: hue-tsi.wu@uct.ac.za
Immunohistochemical investigation for invadopodia formation in cervical squamous cell carcinoma
Contact UCT investigator: Hue-Tsi Wu
Email address: hue-tsi.wu@uct.ac.za
Primary health care providers knowledge and management of symptoms suggestive of cervical cancer
Contact UCT investigator: Jennifer Moodley
Email address: jennifer.moodley@uct.ac.za
Improving timely diagnosis of symptomatic breast and cervical cancer in Sub-Saharan Africa
Contact UCT investigator: Jennifer Moodley
Email address: jennifer.moodley@uct.ac.za
A discourse analysis of the academic literature about cervical cancer in Africa
Contact UCT investigator: Jennifer Moodley
Email address: jennifer.moodley@uct.ac.za
Advancing early diagnosis of cervical cancer in Southern Africa - the African aWAreness of CANcer and Early Diagnosis (AWACAN-ED) project
Contact UCT investigator: Jennifer Moodley
Email address: jennifer.moodley@uct.ac.za
Regulation of HPV infection and cervical cancer progression following helminth infection
Contact UCT investigator: Katherine Smith
Email address: katie.smith@uct.ac.za
Modelling the impact of prevention strategies on cervical cancer incidence in South Africa
Contact UCT investigator: Leigh Johnson
Email address: leigh.johnson@uct.ac.za
The Role of MRI in Early Cervical Cancer
Contact UCT investigator: Linda Rogers
Email address: linda.rogers@uct.ac.za
Improving the specificity of HPV Screen-and-Treat in South Africa
Contact UCT investigator: Lynette Denny
Email address: lynette.denny@uct.ac.za
Therapeutic vaccine against HPV types 16 and 18
Contact UCT investigator: Lynette Denny
Email address: lynette.denny@uct.ac.za
Long term outcomes of women treated for HSIL at a university teaching hospital colposcopy unit in South Africa: a 5 year retrospective cohort study.
Contact UCT investigator: Lynette Denny
Email address: lynette.denny@uct.ac.za
Audit of indications for and outcomes of cone biopsies performed at GSH colposcopy clinic
Contact UCT investigator: Lynette Denny
Email address: lynette.denny@uct.ac.za
Automated Visual Evaluation for Cervical cancer screening
Contact UCT investigator: Lynette Denny /Rakiya Saidu
Email address: lynette.denny@uct.ac.za / rakiya.saidu@uct.ac.za
Studies on Screen and Treat using HPV testing (Phase 2)
Contact UCT investigator: Lynette Denny /Rakiya Saidu
Email address: lynette.denny@uct.ac.za / rakiya.saidu@uct.ac.za
Repurposing of commercial drugs that target the oncogenic TBX2 and TBX3 for anti-cancer activity
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
A cross-sectional, combined methods study: women diagnosed with invasive cervical cancer presenting to Groote Schuur Hospital
Contact UCT investigator: Tracey Adams
Email address: tracey.adams@uct.ac.za
The impact of positive margins and crypt involvement in Large Loop Excision of the Transformation Zone (LLETZ) on recurrence rate of premalignant disease of the cervix
Contact UCT investigator: Tracey Adams
Email address: tracey.adams@uct.ac.za
Investigation of the status and oncogenic function of TBX3 in cervical cancer
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
Investigation into the interaction and cooperation between the human papillomavirus oncoproteins E6/E7 with the oncogenic TBX3 transcription factor to promote cervical cancer cell proliferation and migration
Contact UCT investigator: Sharon Prince/Georgia Schafer
Email address: sharon.prince@uct.ac.za/georgia.schafer@uct.ac.za
Investigating the effect on inhibiting KpnB1 mediated nuclear import in combination with cisplatin in cervical cancer
Contact UCT investigator: Virna Leaner
Email address: virna.leaner@uct.ac.za
The use of nuclear transport proteins as potential novel biomarkers for the detection of cervical cancers
Contact UCT investigator: Virna Leaner
Email address: virna.leaner@uct.ac.za
Closed
Diagnostic immunohistochemical markers of serous carcinomas of the female genital tract
Contact UCT investigator: Hue-Tsi Wu
Email address: hue-tsi.wu@uct.ac.za
Investigating women’s sexuality post gynaecological cancer treatment at Groote Schuur Hospital
Contact UCT investigator: Jennifer Moodley
Email address: jennifer.moodley@uct.ac.za
An exploration of symptom burden among breast and gynaecological cancer patients accessing care at University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria
Contact UCT investigator: Liz Gwyther
Email address: liz.gwyther@uct.ac.za
Frere Oncology Unit database of Women diagnosed with Gynaecological Cancers from 1998 to present
Contact UCT investigator: Lynette Denny
Email address: lynette.denny@uct.ac.za
Mthatha Oncology Unit Database of women diagnosed with gynaecological cancers from 1998 to 2025
Contact UCT investigator: Lynette Denny
Email address: lynette.denny@uct.ac.za
Closed
International ovarian & testicular stromal tumour registry
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
Diagnostic immunohistochemical markers of serous carcinomas of the female genital tract
Contact UCT investigator: Hue-Tsi Wu
Email address: hue-tsi.wu@uct.ac.za
A Randomized Phase 3, Double-Blind Study of Chemotherapy With or Without Pembrolizumab Followed by Maintenance With Olaparib or Placebo for the First- Line Treatment of BRCA non-mutated Advanced Epithelial Ovarian Cancer (EOC)
Contact UCT investigator: Nazia Fakie
Email address: n.fakie@uct.ac.za
Management of women with advance ovarian cancer treated with primary surgery compared to neoadjuvant chemotherapy followed by surgery
UCT investigator: Nomonde Mbatani
Email address: nomonde.mbatani@uct.ac.za
Lynch Syndrome
Contact UCT investigator: Paul Goldberg
Email address: paul.goldberg@uct.ac.za
Ethnic differences in the genetic and molecular profile of women diagnosed with ovarian cancer
Contact UCT investigator: Tracey Adams
Email address: tracey.adams@uct.ac.za
Closed
Identification of biomarkers for prediction of prognosis of women with endometrial cancers
UCT investigator: Nomonde Mbatani
Email address: nomonde.mbatani@uct.ac.za
Prevalence of Gynaecological disease in Women with an HLM1 Mutation in the Northern Cape Province, South Africa. Study of a population with Lynch Syndrome.
UCT investigator: Nomonde Mbatani
Email address: nomonde.mbatani@uct.ac.za
Lynch Syndrome
Contact UCT investigator: Paul Goldberg
Email address: paul.goldberg@uct.ac.za
Closed
Sentinel Lymph Node Biopsy for Early Vulval Cancer in a Limited Resource Setting
UCT investigator: Linda Rogers
Email address: linda.rogers@uct.ac.za
Prognostic importance of immune cells in vulvar cancer
Contact UCT investigator: Lynette Denny /Rakiya Saidu
Email address: lynette.denny@uct.ac.za / rakiya.saidu@uct.ac.za
HPV genotyping of women with vulval carcinoma in HIV positive and negative women and evaluation of immune status
Contact UCT investigator: Lynette Denny /Rakiya Saidu
Email address: lynette.denny@uct.ac.za / rakiya.saidu@uct.ac.za
Vulval cancer review at GSH with emphasis on HPV associated disease
Contact UCT investigator: Tracey Adams
Email address: tracey.adams@uct.ac.za
Closed
The impact of Ephrin Receptor A2 polymorphisms on KSHV infectivity and Kaposi's Sarcoma incidence and severity in HIV/AIDS patients in South Africa
Contact UCT investigator: Georgia Schäfer
Email address: georgia.schäfer@uct.ac.za
Diagnosis, treatment and survival of HIV-infected patients with Kaposi sarcoma in the era of cART: a chart review
Contact UCT investigator: Zainab Mohamed
Email address: zainab.mohamed@uct.ac.za
Retrospective review of patients with Epidemic Kaposi sarcoma treated between 2010 and 2014 at Groote Schuur Hospital
Contact UCT investigator: Zainab Mohamed
Email address: zainab.mohamed@uct.ac.za
Closed
Adapted Treatment Regimens for Hepatoblastoma and AML
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
Normalization of tumour metabolism to modulate radiation response
Contact UCT investigator: Alistair Hunter
Email address: alistair.hunter@uct.ac.za
Myeloproliferative neoplasms
Contact UCT investigator: Estelle Verburgh
Email address: estelle.verburgh@uct.ac.za
Closed
Adapted Treatment Regimens for Hepatoblastoma and AML
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
Palliative drainage of malignant hilar bile duct obstruction in Academic Hospitals in the Western Cape
Contact UCT investigator: Eduard Jonas
Email address: eduard.jonas@uct.ac.za
Do Hepatitis B and HIV interact in the aetiology of hepatocellular carcinoma
Contact UCT investigator: Michael Kew
Email address: michael.kew@uct.ac.za
Closed
Normalization of tumour metabolism to modulate radiation response
Contact UCT investigator: Alistair Hunter
Email address: alistair.hunter@uct.ac.za
Identification and investigation of factors modulating tumour resistance to cytotoxic challenge in the context of mitochondrially-determined cell death
Contact UCT investigator: Alistair Hunter / Michelle Parker
Email address: alistair.hunter@uct.ac.za / michelle.parker@uct.ac.za
Closed
Aggressive Lymphoma: diagnostic pathway, treatment and differential diagnosis
Contact UCT investigator: Estelle Verburgh
Email address: estelle.verburgh@uct.ac.za
Establishing "best-care" diagnostic pathway for investigation of lymphadenopathy
Contact UCT investigator: Estelle Verburgh / Katherine Antel
Email address: estelle.verburgh@uct.ac.za / katherine.antel@uct.ac.za
Hodgkin lymphoma CD 68 prognostic score
Contact UCT investigator: Estelle Verburgh / Katherine Antel
Email address: estelle.verburgh@uct.ac.za / katherine.antel@uct.ac.za
Hodgkin lymphoma in South African children and adolescents from 2000-2010: A first report by the South African Children’s Cancer Study Group (SACCSG)
Contact UCT investigator: Marc Hendricks
Email address: marc.hendricks@uct.ac.za
Biomarker identification in HIV and non-HIV related diffuse large B cell lymphomas
Contact UCT investigator: Richard Naidoo
Email address: richard.naidoo@uct.ac.za
Investigation of the molecular mechanisms of HIV-induced Burkitt’s lymphoma development
Contact UCT investigator: Shaheen Mowla
Email address: shaheen.mowla@uct.ac.za
The medicinal plant extract of Dodonaea viscosa, used by Cape Bush doctors, as adjunct therapy for cancer
Contact UCT investigator: Shaheen Mowla
Email address: shaheen.mowla@uct.ac.za
The cooperation of EBV and HIV in the development of HIV-associated Burkitt lymphoma.
Contact UCT investigator: Shaheen Mowla
Email address: shaheen.mowla@uct.ac.za
A comparison of B-cell and T-cell populations and activation markers of Diffuse Large B-cell Lymphoma HIV positive and HIV negative cases at Groote Schuur hospital.
Contact UCT investigator: Shaheen Mowla
Email address: shaheen.mowla@uct.ac.za
The prevalence of MYD88 and CD79B mutations in DLBCL cases referred to Groote Schuur hospital – a retrospective study.
Contact UCT investigator: Shaheen Mowla
Email address: shaheen.mowla@uct.ac.za
The molecular and functional significance of SOCS1 in lymphomagenesis.
Contact UCT investigator: Shaheen Mowla
Email address: shaheen.mowla@uct.ac.za
A randomized controlled double blind phase III trial to compare the efficacy, safety and pharmacokinetics of GP2013 plus cyclophosphamide, vincristine, prednisone, followed by GP2013 or MabThera Contact UCTtenance therapy in patients with previously untreated, advanced stage follicular lymphoma
Contact UCT investigator: Zainab Mohamed
Email address: zainab.mohamed@uct.ac.za
HIV-associated Muilticentric Castleman's Disease: A Clinical Review of 53 cases presenting to a single institution in South Africa
Contact UCT investigator: Zainab Mohamed
Email address: zainab.mohamed@uct.ac.za
A Randomized, Double-Blind, Multi-center, Multi-national Trial to Evaluate the Efficacy, Safety and Immunogenicity of SAIT101 Versus Rituximab as First-line Immunotherapy Treatment in Patients with Low Tumor Burden Follicular Lymphoma
Contact UCT investigator: Zainab Mohamed
Email address: zainab.mohamed@uct.ac.za
Closed
Cancer testis antigens in multiple myeloma
Contact UCT investigator: Karen Shires
Email address: karen.shires@uct.ac.za
Mage antigen expression: A tool for malignant cell identification, disease monitoring and determining diseases mechanisms
Contact UCT investigator: Karen Shires
Email address: karen.shires@uct.ac.za
Closed
Natural history and outcome in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) at a single tertiary center
Contact UCT investigator: Eduard Jonas
Email address: eduard.jonas@uct.ac.za
A prospective, randomised, Controlled, Open-label, Multicentre phase III study to evaluate efficacy and safety of Peptide Receptor Radionuclide Therapy (PRRT) with 177Lu-Edotreotide compared to targeted molecular therapy with Everolimus in patients with inoperable, progressive, somato-statin receptor-positive (SSTR+), neuroendocrine tumours of gastroenteric or pancreatic origin (GEP-NET)
Contact UCT investigator: Barbara Robertson / R Steyn
Email address: barbara.robertson@uct.ac.za
Closed
Cancer service delivery and the impact of the COVID-19 pandemic in Sub-Saharan Africa
Contact UCT investigator: Jennifer Moodley
Email address: jennifer.moodley@uct.ac.za
Incorporation of cancer control measure into demographic health surveys
Contact UCT investigator: Jennifer Moodley
Email address: jennifer.moodley@uct.ac.za
Radiation-induced motility of cancer cells in vitro
Contact UCT investigator: Alistair Hunter
Email address: alistair.hunter@uct.ac.za
Conserving the integrity of recombinant immunodiagnostics/-therapeutics by compatible solutes.
Contact UCT investigator: Anathi Nkayi /Stefan Barth
Email address: nkyana001@myuct.ac.za / stefan.barth@uct.ac.za
Mitochondrial flux in cell death processes induced by cancer therapy
Contact UCT investigator: Andre Hendrikse
Email address: andre.hendrikse@uct.ac.za
The effect of drug or carcinogen treatment on differential expression of drug metabolism genes in cancer cells
Contact UCT investigator: Collet Dandara
Email address: collet.dandara@uct.ac.za
Development of a cancer survivorship plan for South Africa
Contact UCT investigator: Delva Shamley
Email address: delva.shamley@uct.ac.za
Quantifying the interaction of antibody based fusion proteins with primary cell and tissues of African patients
Contact UCT investigator: Dharanidharan Ramamurthy /Stefan Barth
Email address: dharanidharan.ramamurthy@uct.ac.za / stefan.barth@uct.ac.za
Adapting CAREX (CARcinogen EXposure) tool for occupational exposures in South Africa
Contact UCT investigator: Hanna-Andrea Rother
Email address: andrea.rother@uct.ac.za
A bibliometric analysis of cancer research in South Africa
Contact UCT investigator: Jennifer Moodley
Email address: jennifer.moodley@uct.ac.za
Collecting cancer-related data in large population surveys in low- and middle-income countries: A methodological appraisal of the demographic and health surveys
Contact UCT investigator: Jennifer Moodley
Email address: jennifer.moodley@uct.ac.za
Establishment of recombinant antibody technology platforms for the development of diagnostically- and therapeutically-applied fusion proteins
Contact UCT investigator: Krupa Naran /Stefan Barth
Email address: krupa.naran@uct.ac.za / stefan.barth@uct.ac.za
Impact of cisplatin-induced hearing loss on health-related quality of life: A prospective cohort study
Contact UCT investigator: Lebogang Ramma
Email address: lebogang.ramma@uct.ac.za
Patient preferences & priorities for end-of-life care at Tiyanjane Palliative Care clinic, Blantyre, Malawi
Contact UCT investigator: Linda Ganca
Email address: linda.ganca@uct.ac.za
Loss, Grief & bereavement: Experiences of immigrants receiving Palliative Care Services at Met’Impilo Care Centre
Contact UCT investigator: Linda Ganca
Email address: linda.ganca@uct.ac.za
Understanding the Dignity Experience and Assessing the Impact of a Modified Dignity Psychotherapy Intervention in Patients with Terminal Illness
Contact UCT investigator: Liz Gwyther
Email address: liz.gwyther@uct.ac.za
Investigating how South African oncologist manage depression in late stage cancer patients
Contact UCT investigator: Liz Gwyther
Email address: liz.gwyther@uct.ac.za
An evaluation of patients’ palliative care needs and their response to implementation of individualized care plans initiated at a tertiary oncology service
Contact UCT investigator: Liz Gwyther
Email address: liz.gwyther@uct.ac.za
A study to explore the factors that influence family caregivers of patients receiving palliative care for island Hospice to seek help at emergency
Contact UCT investigator: Liz Gwyther
Email address: liz.gwyther@uct.ac.za
An assessment of the quality of care provided to patients who died in the care of Tshwane district hospital
Contact UCT investigator: Liz Gwyther
Email address: liz.gwyther@uct.ac.za
Prevention of chemotherapy induced alopecia with scalp cooling – does hair curl influence outcome?
Contact UCT investigator: Nonhlanhla Khumalo/ Henry Adeola
Email address: nonhlanhla.khumalo@uct.ac.za / henry.adeola@uct.ac.za
Generation and evaluation of novel CD64-specific immunodiagnostic and therapeutic tools to selectively eliminate dysregulated macrophages in chronic diseases
Contact UCT investigator: Olusiji Alex Akinrinmade /Stefan Barth
Email address: aknolu025@myuct.ac.za / stefan.barth@uct.ac.za
Comparative assessment of different hosts for expression of recombinant immunopharmaceuticals
Contact UCT investigator: Precious Hlongwane / Stefan Barth
Email address: hlnpre001@myuct.ac.za / stefan.barth@uct.ac.za
A determination of the prevalence and reasons why palliative care patients present to the Groote Schuur Hospital Emergency Department
Contact UCT investigator: Radha Govender/Rene Krause
Email address: radha@redchilli.co.za / rene.krause@uct.ac.za
Investigating the role of genetic variation in OTOS in response to cisplatin induced ototoxicity in South African Cancer patients
Contact UCT investigator: Raj Ramesar
Email address: Raj.ramesar@uct.ac.za
The genetics of anthracycline-induced cardiotoxicity in cancer patients
Contact UCT investigator: Raj Ramesar
Email address: Raj.ramesar@uct.ac.za
Identifying patients for Palliative Care in South Africa
Contact UCT investigator: Rene Krause / Liz Gwyther
Email address: rene.krause@uct.ac.za / liz.gwyther@uct.ac.za
Development of novel metallodrugs based on platinum group metals for treating cancer
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
Process optimisation and scale-up for production of immunotherapeutic recombinant fusion proteins
Contact UCT investigator: Sikozile Ncembu /Stefan Barth
Email address: ncmsik001@myuct.ac.za / stefan.barth@uct.ac.za
Establishment of Recombinant Antibody Technologies Allowing the Generation of Disease Specific Immunodiagnostics and Therapeutics
Contact UCT investigator: Trishana Nundalall /Stefan Barth
Email address: nndtri001@myuct.ac.za / stefan.barth@uct.ac.za
Nuclear Transport Proteins as cancer therapeutic targets
Contact UCT investigator: Virna Leaner
Email address: virna.leaner@uct.ac.za
Targeted proteomic approaches to identify novel cancer biomarkers.
Contact UCT investigator: Virna Leaner
Email address: virna.leaner@uct.ac.za
Investigating the effect of novel small molecule inhibitors of KpnB1 on cell cycle progression and apoptosis in cancer cells
Contact UCT investigator: Virna Leaner
Email address: virna.leaner@uct.ac.za
An analysis of oral morphine of oral morphine use at primary health care facilities in the Cape Town Metro
Contact UCT investigator: Rene Krause
Email address: rene.krause@uct.ac.za
Closed
A phase 3 randomized double-blind clincal study of pembrolizumab (MK-3475) plus chemotherapy as first-line treatment in participants with HER-2 negative, previously untreated, unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma (KEYNOTE-859)
Contact UCT investigator: Barbara Robertson
Email address: barbara.robertson@uct.ac.za
Patient and tumour characteristics as prognostic factors in oesophageal cancer: survival analysis
Contact UCT investigator: Collet Dandara
Email address: Collet.dandara@uct.ac.za
Hospital based oesophageal cancer registry
Contact UCT investigator: Iqbal Parker
Email address: Iqbal.parker@uct.ac.za
Molecular biology and molecular markers of oesphageal cancer
Contact UCT investigator: Iqbal Parker
Email address: Iqbal.parker@uct.ac.za
Whole genome sequence analysis of African oesophageal squamous cell carcinoma
Contact UCT investigator: Iqbal Parker
Email address: Iqbal.parker@uct.ac.za
The medicinal plant extract of Dodonaea viscosa, used by Cape Bush doctors, as adjunct therapy for cancer
Contact UCT investigator: Shaheen Mowla
Email address: shaheen.mowla@uct.ac.za
Closed
Analysis of the expression profile and antigenicity of cancer-testis antigens and of urinary biomarkers in pancreatic adenocarcinoma and chronic pancreatitis
Contact UCT investigator: Eduard Jonas
Email address: eduard.jonas@uct.ac.za
A prospective, longitudinal, observational study to assess the health related quality of life of patients with pancreatic adenocarcinoma in South Africa
Contact UCT investigator: Eduard Jonas / Urda Kotze
Email address: eduard.jonas@uct.ac.za / urda.kotze@uct.ac.za
A systematic review and meta-analysis to assess the equivalence of survival of patients with borderline resectable and unresectable locally advanced pancreatic ductal adenocarcinoma
Contact UCT investigator: Eduard Jonas
Email address: eduard.jonas@uct.ac.za
Palliative care audit on pancreatic adenocarcinoma cancer patients in Groote Schuur hospital
Contact UCT investigator: Rene Krause
Email address: rene.krause@uct.ac.za
Investigation of the status and oncogenic function of TBX2/TBX3 in pancreatic cancer
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
Repurposing drugs that target the oncogenic TBX2 and TBX3 to treat pancreatic cancer
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
Closed
The medicinal plant extract of Dodonaea viscosa, used by Cape Bush doctors, as adjunct therapy for cancer
Contact UCT investigator: Shaheen Mowla
Email address: shaheen.mowla@uct.ac.za
Closed
Salivary gland rescue to overcome radiotherapy-induced xerostomia
Contact UCT investigator: Alistair Hunter
Email address: alistair.hunter@uct.ac.za
Closed
The impact of Ephrin Receptor A2 polymorphisms on KSHV infectivity and Kaposi's Sarcoma incidence and severity in HIV/AIDS patients in South Africa
Contact UCT investigator: Georgia Schäfer
Email address: georgia.schafer@uct.ac.za
A randomized controlled study of yondelis (trabectedin) or dacarbazine for the treatment of advanced liposarcoma or leiomyosarcoma
Contact UCT investigator: Jeanette Parkes
Email address: jeanette.parkes@uct.ac.za
Overexpression of the T-box transcription factor, TBX3, as an early marker of sarcomas
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
Investigating novel drugs and drug targets for the treatment of rhabdomyosarcoma
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
Diagnosis, treatment and survival of HIV-infected patients with Kaposi sarcoma in the era of cART: a chart review
Contact UCT investigator: Zainab Mohamed
Email address: zainab.mohamed@uct.ac.za
Retrospective review of patients with Epidemic Kaposi sarcoma treated between 2010 and 2014 at Groote Schuur Hospital
Contact UCT investigator: Zainab Mohamed
Email address: zainab.mohamed@uct.ac.za
C-myc, TBX3 and nucleolin as combination biomarkers for the reliable diagnosis of several sarcoma subtypes
Contact UCT investigator: Sharon Prince/ Dhiren Govender/ Jeannette Parkes/ Komala Pillay
Email address: sharon.prince@uct.ac.za
The role of the oncogenic TBX3 and nucleolin in the malignant transformation of mesenchymal stem/stromal cells into sarcoma subtypes
Contact UCT investigator: Sharon Prince/ Jeannette Parkes/ Komala Pillay
Email address: sharon.prince@uct.ac.za
Marine-derived chromomycin A5: a novel strategy to treat TBX2-driven rhabdomyosarcoma
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
Closed
Proteomic studies on patient responses to vaccination and chemotherapy/ radiotherapy in melanoma
Contact UCT investigator: Jonathan Blackburn
Email address:Jonathan.blackburn@uct.ac.za
Identification of novel drugs and drug targets for treating melanoma
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
An investigation of the phenotypic switching of dermal fibroblasts to cancer associated fibroblasts in the melanoma tumour microenvironment
Contact UCT investigator: Sharon Prince
Email address: sharon.prince@uct.ac.za
Evaluation of tumour associated antigens to optically label cutaneous basal cell carcinoma for surgical excision
Contact UCT investigator: Stefan Barth / Nonhlanhla Khumalo
Email address: stefan.barth@uct.ac.za / n.khumalo@uct.ac.za
Closed
Review of surgical management primary spine tumours in adult and paediatric population
Contact UCT investigator: Robert Dunn
Email address:Robert.dunn@uct.ac.za
Closed
International Ovarian & Testicular Stromal Tumour Registry
Contact UCT investigator: Alan Davidson
Email address: alan.davidson@uct.ac.za
Closed
Genetics of thyroid carcinoma to develop cost-effective management
Contact UCT investigators: Ian Ross / Collet Dandara
Email address: Ian.ross@uct.ac.za / Collet.dandara@uct.ac.za
Closed
Closed