Completed:
| A Prospective Epidemiological Study of TB Disease and TB Infection in Adolescents in the Worcester and Surrounding Areas, Western Cape Province, South Africa. | Compare the T-cell cytokine profile induced by novel latency associated and highly recognized Mtb proteins in 2 groups. The differences will be measured in T-cells obtained from blood stimulated for a short or long period. Immune proteins such as IFN-g, IL2 and TNFα will be measured either inside the cell by intracellular cytokine staining and multi-parameter flow cytometry. The immune proteins released by the cells will be measured by ELISA. | Machingaidze et al. Am J Respir Crit Care Med. 2012 - Mahomed et al. PLoS One. 2011 Mahomed et al. Int J Tuberc Lung Dis. 2011 |
| A Prospective Epidemiological Study of TB in Neonates in Worcester and Surrounding Areas, Western Cape Province, South Africa to Determine the Impact of Surveillance Methodology on the Measurement of the Incidence of Pulmonary Tuberculosis. | To compare the cumulative incidence of smear and/or culture positive tuberculosis in a cohort of neonates in the greater Worcester area from birth to two years of age who are randomized to one of two case surveillance methodologies. The study was conducted from 2005-2008, with 4,786 infants participating from the study community. | |
| Protocol for an Observational Study to Assess the Effect of the Change in BCG Policy on Tuberculosis in the Cape Metropole. | The purpose of this study is to quantify any change in the incidence of all tuberculosis and severe tuberculosis in children less than 2 years of age that occurred following the change in BCG strain and method of administration employed. The study was conducted from 2000-2004, with a PC cohort of 1,369 and an ID cohort of 1,397. | Mahomed et al. Pediatr Infect Dis J 2006 |
| Survey of tuberculosis infection in healthy adult volunteers in the Boland health region. | The primary objective of this study is to estimate the prevalence of healthy adults in the Worcester community of Western Cape Province South Africa with a negative (TB<15% of mitogen) Quantiferon®-TB test result. This cross-sectional study of 358 healthy adults was conducted. | Mahomed et al. Int J Tub Lung Dis 2006 |