Prof Mpiko Ntsekhe

Mpiko Ntsekhe MD., PhD., Cert Cardiology., FACC., MASSAf


Helen and Morris Mauerberger Professor and Chair of Cardiology, University of Cape Town


Head: Division of Cardiology, Groote Schuur Hospital


Contact Details         


Work Address: E-17 Cardiac Clinic, New Groote Schuur Hospital, Anzio Road Observatory 7925

Email Address:

Work Telephone: 021-404-6084

Fax: 021-448-7062


Academic Qualifications


·       BA (Brown University, USA)

·       MD (Columbia University College of Physicians and Surgeons, USA)

·       MPhil (UCT, SA)

·       PhD (UCT, SA)

·       FCP (SA)

·       Certificate in Cardiology (SA)


Employment History


·       Current-Helen and Morris Mauerberger Professor and Chair of Cardiology, University of Cape Town and Head: Division of Cardiology, Groote Schuur Hospital

·       2005-2012: Consultant Cardiologist & Director of Cardiac Catheterization Division of Cardiology, Groote Schuur Hospital.  Senior Lecturer, Department of Medicine, University of Cape Town

·       2007-2009: Edith Sorrel Research Fellow, Department of Medicine, University of Cape Town

·       2004-2007: Consultant Cardiologist, Division of Cardiology, Groote Schuur Hospital




·       Fellow-American College of Cardiology (FACC)

·       Member -Academy of Science of South African (MASSAf)

·       Fellow-University of Cape Town College of Fellows

·       Member-Sigma Xi Scientific Research Honor Society

·       SA MRC Lifetime Contributions to Science in Silver-2021


Teaching and Training


·       Master’s degree supervised to completion (MSc/MPhil/MMED): 19

·       PhDs supervised to completion: 4

·       Masters/MDs/PhDs currently under supervision-12


Research Activities and Academic Output


Editorial Board Activities

·       Circulation: Cardiovascular Quality and Outcomes:  2016-current

·       EuroIntervention: January 2018-current

·       Heart Asia: January 2016-2020

Journal Review Activities

·       Reviewer for > 30  journals including European Heart Journal, Circulation, JACC, Plos Medicine, JACC

 Grant Review Activities

·       grant reviewer for the following bodies. NRF (SA), SAMR, SA Heart, Canadian Institute for Health Research, UK MRC, Industry Research Grants


Complete List of Published Work via PubMed:



·       151 publications in peer reviewed journals

·       7-Book Chapters

·       H index 30



Sample publications


1.      Ntsekhe M, Baker JV. Cardiovascular Disease Among Persons Living with HIV: New Insights Into Pathogenesis and Clinical Manifestations in a Global Context. Circulation. 2023 Jan 3;147(1):83-100.

2.      Stuart J Connolly, Ganesan Karthikeyan, Mpiko Ntsekhe for the Invictus Investigators Rivaroxaban in Rheumatic Heart Disease-Associated Atrial Fibrillation.N Engl J Med 2022 Sep 15;387(11):978-988

3.      Roth GA, Mensah GA, Johnson CO et al for the ACC Global Burden of Cardiovascular Diseases Writing Group. Global burden of cardiovascular disease and Risk Factors, 1990-2019: Update from the GBD 2019 Study. J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021

4.      Howlett P, Du Bruyn E, Morrison H, Godsent IC, Wilkinson KA, Ntsekhe M, Wilkinson RJ. The Immunopathogenesis of tuberculous pericarditis. Microbes Infect. 2020 May-Jun;22(4-5):172-181.

5.      Noubiap JJ, Agbor VN, Ndoadoumgue AL, Nkeck JR, Kamguia A, Nyaga UF, Ntsekhe M Epidemiology of pericardial diseases in Africa: a systematic scoping review Heart. 2019 Feb;105(3):180-188

6.      Kengne AP, Ntsekhe M. Challenges of Cardiovascular Disease Risk Evaluation in People Living with HIV Infection. Circulation. 2018 May 22;137(21):2215-2217.

7.      Keates AK, Mocumbi AO, Ntsekhe M, Sliwa K, Stewart S. Cardiovascular disease in Africa: epidemiological profile and challenges.Nat Rev Cardiol. 2017 May;14(5):273-293

8.      Wiysonge CS, Ntsekhe M, Thabane L, Volmink J, Majombozi D, Gumedze F, Pandie S, Mayosi BM

Interventions for treating tuberculous pericarditis. Cochrane Database Syst Rev. 2017 Sep 13;9:CD000526.

9.      Mayosi BM, Ntsekhe M, et al IMPI Trial Investigators. Prednisolone and Mycobacterium indicus pranii in tuberculous pericarditis   N Engl J Med. 2014 Sep 18;371(12):1121-30

10.    Esmail H, Oni T, Thienemann F, Omar-Davies N, Wilkinson RJ, Ntsekhe M.

Cardio-Thoracic Ratio is Stable, Reproducible and Has Potential as a Screening Tool for HIV-1 Related Cardiac Disorder in Resource Poor Settings. PLoS One. 2016 Oct 4;11(10


Clinical Trial Experience as National PI and/or Trial  Steering Committee Member (Last 5 years)


·       Remote Ischemic Conditioning in STEMI Patients in Sub-Saharan AFRICA: The RIC-AFRICA Trial

·       IMPI-3 - A Randomized Controlled Trial of High vs. Standard Dose Rifampicin for Effusive Tuberculous Pericarditis

·       INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies

·       HERMES: Effects of Ziltivekimab Versus Placebo on Morbidity and Mortality in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation

·       A Trial of Complete Percutaneous Pericardial Drainage Facilitated by Intrapericardial Alteplase Compared to Conventional Pericardiocentesis When Indicated in Adults With Large Pericardial Effusion Due to Tuberculous and Non-tuberculous Pericarditis

·       Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD (Lp(a)HORIZON)

·       Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome (AEGIS-II)


International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) (

Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI (PARADISE-MI)  (

·       Study of Vericiguat in Participants With Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-001) (VICTORIA) (

·       Complete vs Culprit-only Revascularization to Treat Multi-vessel Disease After Early PCI for STEMI (COMPLETE)   (