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Mpiko Ntsekhe MD., PhD., Cert Cardiology., FACC., MASSAf
Helen and Morris Mauerberger Professor and Chair of Cardiology, University of Cape Town
Head: Division of Cardiology, Groote Schuur Hospital
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Contact Details
Work Address: E-17 Cardiac Clinic, New Groote Schuur Hospital, Anzio Road Observatory 7925 Email Address: mpiko.ntsekhe@uct.ac.za Work Telephone: 021-404-6084 Fax: 021-448-7062
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Academic Qualifications
· BA (Brown University, USA) · MD (Columbia University College of Physicians and Surgeons, USA) · MPhil (UCT, SA) · PhD (UCT, SA) · FCP (SA) · Certificate in Cardiology (SA)
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Employment History
· Current-Helen and Morris Mauerberger Professor and Chair of Cardiology, University of Cape Town and Head: Division of Cardiology, Groote Schuur Hospital · 2005-2012: Consultant Cardiologist & Director of Cardiac Catheterization Division of Cardiology, Groote Schuur Hospital. Senior Lecturer, Department of Medicine, University of Cape Town · 2007-2009: Edith Sorrel Research Fellow, Department of Medicine, University of Cape Town · 2004-2007: Consultant Cardiologist, Division of Cardiology, Groote Schuur Hospital
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Honors/Awards
· Fellow-American College of Cardiology (FACC) · Member -Academy of Science of South African (MASSAf) · Fellow-University of Cape Town College of Fellows · Member-Sigma Xi Scientific Research Honor Society · SA MRC Lifetime Contributions to Science in Silver-2021
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Teaching and Training
· Master’s degree supervised to completion (MSc/MPhil/MMED): 19 · PhDs supervised to completion: 4 · Masters/MDs/PhDs currently under supervision-12
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Research Activities and Academic Output
Editorial Board Activities · Circulation: Cardiovascular Quality and Outcomes: 2016-current · EuroIntervention: January 2018-current · Heart Asia: January 2016-2020 Journal Review Activities · Reviewer for > 30 journals including European Heart Journal, Circulation, JACC, Plos Medicine, JACC Grant Review Activities · grant reviewer for the following bodies. NRF (SA), SAMR, SA Heart, Canadian Institute for Health Research, UK MRC, Industry Research Grants
Complete List of Published Work via PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Ntsekhe+M&sort=date
Summary: · 151 publications in peer reviewed journals · 7-Book Chapters · H index 30
Sample publications
1. Ntsekhe M, Baker JV. Cardiovascular Disease Among Persons Living with HIV: New Insights Into Pathogenesis and Clinical Manifestations in a Global Context. Circulation. 2023 Jan 3;147(1):83-100. 2. Stuart J Connolly, Ganesan Karthikeyan, Mpiko Ntsekhe for the Invictus Investigators Rivaroxaban in Rheumatic Heart Disease-Associated Atrial Fibrillation.N Engl J Med 2022 Sep 15;387(11):978-988 3. Roth GA, Mensah GA, Johnson CO et al for the ACC Global Burden of Cardiovascular Diseases Writing Group. Global burden of cardiovascular disease and Risk Factors, 1990-2019: Update from the GBD 2019 Study. J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021 4. Howlett P, Du Bruyn E, Morrison H, Godsent IC, Wilkinson KA, Ntsekhe M, Wilkinson RJ. The Immunopathogenesis of tuberculous pericarditis. Microbes Infect. 2020 May-Jun;22(4-5):172-181. 5. Noubiap JJ, Agbor VN, Ndoadoumgue AL, Nkeck JR, Kamguia A, Nyaga UF, Ntsekhe M Epidemiology of pericardial diseases in Africa: a systematic scoping review Heart. 2019 Feb;105(3):180-188 6. Kengne AP, Ntsekhe M. Challenges of Cardiovascular Disease Risk Evaluation in People Living with HIV Infection. Circulation. 2018 May 22;137(21):2215-2217. 7. Keates AK, Mocumbi AO, Ntsekhe M, Sliwa K, Stewart S. Cardiovascular disease in Africa: epidemiological profile and challenges.Nat Rev Cardiol. 2017 May;14(5):273-293 8. Wiysonge CS, Ntsekhe M, Thabane L, Volmink J, Majombozi D, Gumedze F, Pandie S, Mayosi BM Interventions for treating tuberculous pericarditis. Cochrane Database Syst Rev. 2017 Sep 13;9:CD000526. 9. Mayosi BM, Ntsekhe M, et al IMPI Trial Investigators. Prednisolone and Mycobacterium indicus pranii in tuberculous pericarditis N Engl J Med. 2014 Sep 18;371(12):1121-30 10. Esmail H, Oni T, Thienemann F, Omar-Davies N, Wilkinson RJ, Ntsekhe M. Cardio-Thoracic Ratio is Stable, Reproducible and Has Potential as a Screening Tool for HIV-1 Related Cardiac Disorder in Resource Poor Settings. PLoS One. 2016 Oct 4;11(10
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Clinical Trial Experience as National PI and/or Trial Steering Committee Member (Last 5 years)
· Remote Ischemic Conditioning in STEMI Patients in Sub-Saharan AFRICA: The RIC-AFRICA Trial https://clinicaltrials.gov/ct2/show/NCT04813159
· Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD (Lp(a)HORIZON) https://clinicaltrials.gov/ct2/show/NCT04023552 · Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome (AEGIS-II) ( https://clinicaltrials.gov/ct2/show/NCT03473223) International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) ( https://clinicaltrials.gov/ct2/show/NCT01471522) Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI (PARADISE-MI) (https://clinicaltrials.gov/ct2/show/NCT02924727) · Study of Vericiguat in Participants With Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-001) (VICTORIA) ( https://clinicaltrials.gov/ct2/show/NCT02861534) · Complete vs Culprit-only Revascularization to Treat Multi-vessel Disease After Early PCI for STEMI (COMPLETE) (https://clinicaltrials.gov/ct2/show/NCT01740479)
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