Dr. Shamely is the Director of the Clinical Research Centre at UCT and has a track record of postgraduate student supervision to PhD level, publications and grant success. She has taught research design and methods to postgraduate students and clinicians in Oxford, Bournemouth and South Africa. External consultancies include peer reviewing journals, grant reviewing for the HTA (UK), NRF (SA), Flanders Foundation (Belgium) and EDCRP (EU).

Her research programmes include proteomics and geonomics of latent effects of adjuvant therapy in breast cancer survivors. Dr. Shamely is also committed to the development of care pathways for post cancer treatment morbidity, which will provide evidence for the Cancer Survivorship Plan for South Africa. The REACH Programme of has two goals: (1). To identify risk factors for the development of upper limb morbidity in breast cancer survivors and (2). To develop integrated care pathways managing Lymphoedema and upper limb pain and disability.

She has developed an Early Warning System (EWS) to identify patients at risk of developing complications in response to treatment. The current EWS is based on clinical risk factors and is being used in the UK and Australia. In addition, she has a team exploring potential systematic causes of morbidity by correlating the clinical phenotype of the shoulder after treatment for breast cancer with biomarkers of inflammation and angiogenesis, and their associated genetic variants.

She is also involved in developing research capacity in collaboration with the African Clinical Trials Consortium and many other NGO’s.

Academic Qualifications

BSc(medicine); BSC Physiotherapy (Hons); PhD; Executive MBA

Positions held

Director: Clinical Research Centre, UCT

Deputy Director; Senior Lecturer: Clinical Research Centre, UCT

Head: Division of Clinical Anatomy and Biological Anthropology, UCT

Co-Director: African Clinical Trials Consortium

Head: Clinical Trials Special Interest Group; AORTIC.

Visiting Professor, University of Enugu, Nigeria.

Chair: AREF Grants Committee

Chair: Harry Crossley Foundation grants, UCT, SA.

Member of Advisory Steering Group and Mentor, Clinical Trials Unit, Oxford Brookes University, Oxford, UK.

Research Output

Peer reviewed Publication Number: 54

NRF rating:C2 (expired)

Scopus H-index:21

Google H-index:16

I10 Index: 22

Google Scholar link or ORCID link

https://scholar.google.co.za/citations?user=vplpK_8AAAAJ&hl=en

https://orcid.org/0000-0003-2355-6629

International and national research collaborations

• Department of Oncology, Groote Schuur Hospital.
• Prof C Dandara, Division of Genetics, UCT.
• CANSA, SA.
• Prof A September, Division of Physiology, Faculty of Health Sciences, UCT.
• Prof N Naidoo and Dr T Burgess, Department of Rehabilitation, UCT.
• Prof I Okoye, Enugu, Nigeria.
• Prof F Odendina, Mayo Clinic, USA.

Recent and noteworthy publications

      2021

Shamley D., Ezeani A and Okoye I. Oncology Clinical Trials in Africa: Partnering for Quality

JCO Global Oncol 7:572-576. © 2021 by American Society of Clinical Oncology

Mafu T, September A and Shamley D. Regulatory VCAN polymorphism is associated with shoulder pain and disability in breast cancer survivors. Human Genomics; 15:36. https://doi.org/10.1186/s40246-021-00337-0

2020

Odedina F, Shamley D, Okoye I, Ndlovu N, Adaora E. et al.  The Landscape of Oncology Clinical Trials in Africa. Journal of Global Oncology; 6: 932-940. https://ascopubs.org/doi/full/10.1200/JGO.19.00189.

Rogers, C. Shamley, D. and Amosun, S. Getting Buy-In: Recruitment and Retention of Older Adults in a Feasibility Cluster Randomized Controlled Trial. SAGE Research Methods Cases: Medicine and Health Methods: Cluster-randomized trials, Case study research, Retention Disciplines: June 25, SAGE Publications Ltd City: London Online ISBN: 9781529743074 DOI: https://dx.doi.org/10.4135/9781529743074 © 2020 SAGE Publications Ltd

2019

Mafu, T., September, A. and Shamley, D. KDR is associated with upper limb dysfunction in breast cancer survivors of mixed- ancestry. Cancer Management and Research, 11: 3829–3845.

Shackleton, C., Evans, R., Shamley, D., West, S. and Albertus, Y.   Effectiveness of Over-Ground Robotic Locomotor Training in Improving Walking Performance, Cardiovascular Demands, Secondary Complications and User-Satisfaction in Individuals With Spinal Cord Injuries: A Systematic Review. J Rehab Med. Oct 29;51(10):723-733.

doi: 10.2340/16501977-2601

2018

Kramer, N, Ramjith, J. and Shamley D. Prevalence of upper limb morbidity in a South African breast cancer population. Support Care Cancer. Jul;27(7):2591-2598;27(7):2591–2598. https://doi.org/10.1007/s00520-018-4540-3.

Botha, B., Shamley, D. and Dyer, S. Availability, effectiveness and safety of assisted reproductive technology in sub-Saharan Africa: a systematic review. Human Reproduction Open.

2017

Mafu T, September A and Shamley D. The role of angiogenesis in the development of shoulder pain, shoulder dysfunction and lymphedema after breast cancer treatment. Canc Management and Treatment. Jan 15;10:81-90. doi: 10.2147/CMAR.S151714. IF3.8.

Nel K, Chi Yuan Nam M, Anstey C, Boos C, Carlton E, Senior R, Kaski JC, Khattab A, Shamley D, Byrne C, and Greaves K. Myocardial Blood Flow Reserve Is Negatively Associated With Aortic Valve Calcification In Patients With Unobstructed Epicardial Coronary Arteries. Int J Cardiol. Dec 1; 248C: pp. 427-432. IF: 4.38. 10.1016/j.ijcard.2017.06.023.

Grants and funding

2018

$40 000.00. NIH/NCI’s Cancer Research Training Travel Awards: African Oncology Clinical Trials Leadership Training and Development program: Increasing Manpower for Clinical Trials in Africa. Grant funded African Oncologist to travel to the Clinical Research Centre for training on clinical trial management and implementation.

R30 000.00. Student Training Grant. UCT, SA.

R24 000.00. International Travel Grant, UCT, SA

2017 - 2019

R500 000.00. CANSA. Development of an integrated care pathway for preventing upper limb complications in South African breast cancer survivors.