Immunopathology of TB: Studying the role of the lymph nodes in the TB spectrum.
Researchers from SATVI and various research collaborators, describe a novel study conducted by the South African Tuberculosis Vaccine Initiative to study the lymph nodes of humans in the context of mycobacterium tuberculosis infection and disease. This study looks at lymph node immunology, and the role of these organs in the progression to TB disease.
The study involved microscopy, microbiology and immunology techniques such as scRNA sequencing or mass cytometry on samples from lymph nodes and blood to identify mechanisms of protection or risk in healthy or sick individuals. The work has been funded with a Wellcome Leap grant.
The research team
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| Dr Virginie Rozot, Lead Investigator, SATVI. | Dr Carlie Young-Bailie, Project Scientist, SATVI. |
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| Dr Laura Taylor, Specialist Forensic Pathologist Division of Forensic Medicine and Toxicology. | Dr Attica Moosa and Dr Dharanidharan Ramamurthy, UCT Molecular Mycobacteriology Research Unit . |
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| Ms Katleho Matlatse, Project Research Assistant, SATVI. | Mr Tim Reed, Senior Scientific Officer, SATVI. |
In the video we interview (1) Dr Virginie Rozot, lead investigator, (2) Dr Carly Young-Bailie project scientist, (3) Dr Laura Taylor, Specialist Forensic Pathologist Division of Forensic Medicine and Toxicology, (4) Ms Katleho Matlatse, Project Research Assistant, (5) Mr Tim Reed, Senior Scientific Officer, at SATVI, (6) Dr Atica Moosa, Research Officer and (7) Dr Dharanidharan Ramamurthy from the UCT Molecular Mycobacteriology Research Unit .
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