Most of the world's malaria deaths occur in Africa and in vulnerable populations. Our group aims to lead research that can improve the treatment of malaria in Africa, and globally. Together with vector control, better treatments will contribute to the control and eventual elimination of malaria. Drug (and insecticide) resistance are the main obstacles to malaria control to elimination. Over the past few years, we have extended our partnerships and collaborations and this has culminated in the formation of CCOAT, linking clinical drug development with evidence synthesis to inform national, regional and global malaria treatment guidelines.