2024
Banda, C. G., Kantonya, M. S., Munharo, S., Chirwa, M. E., Kapulula, M. D., Chavula, H. D., ... & Barnes, K. I. (2024). A pharmacokinetic randomised interventional study to optimise dihydroartemisinin-piperaquine dosing for malaria preventive treatment in Malawian infants: A protocol for the OPTIMAL study. Wellcome Open Research, 9(291), 291.
A pharmacokinetic randomised ... | Wellcome Open Research
Stepniewska, K., Allan, R., Anvikar, A. R., Anyorigiya, T. A., Ashley, E. A., Bassat, Q., ... & Guerin, P. J. (2024). Does acute malnutrition in young children increase the risk of treatment failure following artemisinin-based combination therapy? A WWARN individual patient data meta-analysis. The Lancet Global Health, 12(4), e631-e640.
DOI:https://doi.org/10.1016/S2214-109X(24)00003-2
Kagoro, F. M., Allen, E., Raman, J., Mabuza, A., Magagula, R., Kok, G., ... & Barnes, K. I. (2024). Factors Affecting Integration of an Early Warning System for Antimalarial Drug Resistance within a Routine Surveillance System in a Pre-elimination Setting in Sub-Saharan Africa. medRxiv, 2024-06. doi: https://doi.org/10.1101/2024.06.09.24308667
2023
Takyi, A., Soma, A., Przybylska, M., Harriss, E., Carrara, V., Barnes, K., ... & Stepniewska, K. (2023). PA-340 A systematic review of the efficacy of artemisinin-based combination therapy (ACT) in people living with HIV (PLHIV) diagnosed with uncomplicated Plasmodium falciparum malaria in Africa. BMJ Global Health, 8(Suppl 10).
Takyi, A., Carrara, V. I., Dahal, P., Przybylska, M., Harriss, E., Insaidoo, G., ... & Stepniewska, K. (2023). Characterisation of populations at risk of sub-optimal dosing of artemisinin-based combination therapy in Africa. PLOS Global Public Health, 3(12), e0002059. https://doi.org/10.1371/journal.pgph.0002059
Banda, C. G., Tarning, J., & Barnes, K. I. (2023). Use of population pharmacokinetic‐pharmacodynamic modelling to inform antimalarial dose optimization in infants. British Journal of Clinical Pharmacology.
https://doi.org/10.1111/bcp.16132
Raman, J., & Barnes, K. I. (2023). Ensuring prompt detection and effective treatment of all malaria infections in South Africa. South African General Practitioner, 4(2), 54-58. DOI:https://journals.co.za/doi/10.36303/SAGP.0173
Banda, C. G., Nkosi, D., Allen, E., Workman, L., Madanitsa, M., Chirwa, M., ... & Barnes, K. I. (2023). Erratum for Banda et al.,“Impact of Dolutegravir-Based Antiretroviral Therapy on Piperaquine Exposure following Dihydroartemisinin-Piperaquine Intermittent Preventive Treatment of Malaria in Pregnant Women Living with HIV”. Antimicrobial Agents and Chemotherapy, 67(1), e01562-22. , https://doi.org/10.1128/aac.00584-22
Barnes, K. I., Olliaro, P., & Gomes, M. F. (2023). A legacy of progress in clinical pharmacology and social justice; remembering Peter Ian Folb. Bulletin of the World Health Organization, 101(1), 3.doi: 10.2471/BLT.22.289501
2022
Chughlay, M. F., Chalon, S., El Gaaloul, M., Gobeau, N., Möhrle, J. J., Berghmans, P. J., ... & Barnes, K. I. (2022). Safety, tolerability, and parasite clearance kinetics in controlled human malaria infection after direct venous inoculation of plasmodium falciparum sporozoites: A model for evaluating new blood-stage antimalarial drugs. The American Journal of Tropical Medicine and Hygiene, 107(4), 804. doi: 10.4269/ajtmh.21-1297
Banda, C. G., Nkosi, D., Allen, E., Workman, L., Madanitsa, M., Chirwa, M., ... & Barnes, K. I. (2022). Impact of dolutegravir-based antiretroviral therapy on piperaquine exposure following dihydroartemisinin-piperaquine intermittent preventive treatment of malaria in pregnant women living with HIV. Antimicrobial agents and chemotherapy, 66(12), e00584-22.
DOI: https://doi.org/10.1128/aac.00584-22
Banda CG, Nkosi D, Allen EN, Workman L, Madanitsa M, Chirwa M, Kapulula M, Muyaya S, Munharo S, Tarning J, Phiri KS, Mwapasa V, ter Kuile FO, Maartens G, Barnes KI. Effect of dolutegravir-based antiretroviral therapy on exposure to dihydroartemisinin-piperaquine for malaria intermittent preventive treatment in pregnant women living with HIV. Antimicrobial Agents and Chemotherapy 2022. Published online ahead of print.
Stepniewska K, Allen EN, Humphreys GS, Poirot E, Craig E, Kennon K, Yilma D, Bousema T, Guerin PJ, White NJ, Price RN, Raman J, Martensson A, Mwaiswelo RO, Bancone G, Bastiaens GJH, Bjorkman A, Brown JM, D'Alessandro U, Dicko AA, El-Sayed B, Elzaki SE, Eziefula AC, Gonçalves BP, Hamid MMA, Kaneko A, Kariuki S, Khan W, Kwambai TK, Ley B, Ngasala BE, Nosten F, Okebe J, Samuels AM, Smit MR, Stone WJR, Sutanto I, Ter Kuile F, Tine RC, Tiono AB, Drakeley CJ, Gosling R, Stergachis A, Barnes KI, Chen I. Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data. BMC Med 20, 350 (2022). https://doi.org/10.1186/s12916-022-02504-z
Chughlay MF, Chalon S, El Gaaloul M, Gobeau N, Möhrle JJ, Berghmans PJ, Van Leuven K, Marx MW, Rosanas-Urgell A, Flynn J, Escoffier E, Izquierdo-Juncàs D, Jansen B, Mitov V, Kümmel A, Van Geertruyden JP, Barnes KI. Safety, Tolerability, and Parasite Clearance Kinetics in Controlled Human Malaria Infection after Direct Venous Inoculation of Plasmodium falciparum Sporozoites: A Model for Evaluating New Blood-Stage Antimalarial Drugs. Am J Trop Med Hyg. 2022 Aug 29;107(4):804-814. doi: 10.4269/ajtmh.21-1297.
Flegg JA, Humphreys GS, Montanez B, Strickland T, Jacome-Meza ZJ, Barnes KI, Raman J, Guerin PJ, Hopkins Sibley C, Dahlström Otienoburu S. Spatiotemporal spread of Plasmodium 1 falciparum mutations for resistance to sulfadoxine-pyrimethamine across Africa, 1990 – 2020 PLoS Computational Biology 2022 Aug 11;18(8):e1010317. doi: 10.1371/journal.pcbi.1010317.
Kagoro FM, Allen E, Mabuza A, Workman L, Magagula R, Kok G, Davies C, Malatje G, Guérin PJ, Dhorda M, Maude RJ, Raman J, Barnes KI. Making data map-worthy-enhancing routine malaria data to support surveillance and mapping of Plasmodium falciparum anti-malarial resistance in a pre-elimination sub-Saharan African setting: a molecular and spatiotemporal epidemiology study. Malar J. 2022 Jun 29;21(1):207. doi: 10.1186/s12936-022-04224-4.
Rosenthal PJ, Björkman A, Dhorda M, Djimde A, Dondorp AM, Gaye O, Guerin PJ, Juma E, Kwiatkowski DP, Merson L, Ntoumi F, Price RN, Raman J, Roos DS, Ter Kuile F, Tinto H, Tomko SS, White NJ, Barnes KI. Cooperation in Countering Artemisinin Resistance in Africa: Learning from COVID-19. Am J Trop Med Hyg. 2022 Apr 12;106(6):1568-70. doi: 10.4269/ajtmh.22-0148.
Banda CG, Nkosi D, Allen E, Workman L, Madanitsa M, Chirwa M, Kapulula M, Muyaya S, Munharo S, Wiesner L, Phiri KS, Mwapasa M, Ter Kuile FO, Maartens G, Barnes KI. Effect of dihydroartemisinin / piperaquine for malaria intermittent preventive treatment on dolutegravir exposure in pregnant women living with HIV. J Antimicrob Chemother 2022 May 29;77(6):1733-1737. doi: 10.1093/jac/dkac081.
Weld E, Waitt C, Barnes KI, Garcia-Bournissen F. Twice Neglected? Neglected Diseases in Neglected Populations. Br J Clin Pharmacol 2022;88(2):367-373.
Kagoro FM, Barnes KI, Marsh K, Ekapirat N, Mercado CEG, Sinha I, Humphreys G, Dhorda M, Guerin PJ, Maude RJ. Mapping genetic markers of artemisinin resistance in Plasmodium falciparum malaria in Asia: a systematic review and spatiotemporal analysis. Lancet Microb 2022; 3(3): e184-e192
WorldWide Antimalarial Resistance Network Falciparum Haematology Study Group. Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data. BMC Med. 2022 Mar 7;20(1):85. DOI: 10.1186/s12916-022-02265-
Stepniewska K, Humphreys GS, Gonçalves BP, Craig E, Gosling R, Guerin PJ, Price RN, Barnes KI, Raman J, Smit MR, D'Alessandro U, Stone WJR, Bjorkman A, Samuels AM, Arroyo-Arroyo MI, Bastiaens GJH, Brown JM, Dicko A, El-Sayed BB, Elzaki SG, Eziefula AC, Kariuki S, Kwambai TK, Maestre AE, Martensson A, Mosha D, Mwaiswelo RO, Ngasala BE, Okebe J, Roh ME, Sawa P, Tiono AB, Chen I, Drakeley CJ, Bousema T. Efficacy of Single-Dose Primaquine With Artemisinin Combination Therapy on Plasmodium falciparum Gametocytes and Transmission: An Individual Patient Meta-Analysis. J Infect Dis. 2022 Apr 1;225(7):1215-1226. doi: 10.1093/infdis/jiaa498
2021
Anyorigiya TA, Castel S, Mauff K, Atuguba F, Ogutu B, Oduro A, Dosoo D, Asante KP, Owusu-Agyei S, Dodoo A, Hodgson A, Binka F, Workman LJ, Allen EN, Denti P, Wiesner L, Barnes KI. Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria. Malar J. 2021 Jan 6;20(1):18
Sjögren E; Tarning J; Barnes KI; Jonsson ENA. Physiologically Based Pharmacokinetic Framework for Prediction of Drug Exposure in Malnourished Children. Preprints 2021, 2020120437 (doi: 10.20944/preprints202012.0437.v1).
2020
Stepniewska K, Humphreys GS, Gonçalves BP, Craig E, Gosling R, Guerin PJ, Price RN, Barnes KI, Raman J, Smit MR, D'Alessandro U, Stone WJR, Bjorkman A, Samuels AM, Arroyo-Arroyo MI, Bastiaens GJH, Brown JM, Dicko A, El-Sayed BB, Elzaki SG, Eziefula AC, Kariuki S, Kwambai TK, Maestre AE, Martensson A, Mosha D, Mwaiswelo RO, Ngasala BE, Okebe J, Roh ME, Sawa P, Tiono AB, Chen I, Drakeley CJ, Bousema T. Efficacy of single dose primaquine with artemisinin combination therapy on P. falciparum gametocytes and transmission: A WWARN individual patient meta-analysis. J Inf Dis 2020 doi: 10.1093/infdis/jiaa498.
McGready R, Nosten F, Barnes KI, Mokuolu O, White NJ. Why is WHO failing women with falciparum malaria in the first trimester of pregnancy? Lancet. 2020 Mar 7;395(10226):779. doi: 10.1016/S0140-6736(20)30161-6. No abstract available. PMID: 32145785 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30161-6/fulltext
Chan XHS, Win YN1, Haeusler IL, Tan JY1, Loganathan S, Saralamba S, Chan SKS, Ashley EA, Barnes K, Baiden R, Bassi PU, Djimde A, Dorsey G, Duparc S, Hanboonkunupakarn B, Ter Kuile FO, Lacerda MVG, Nasa, Nosten FH, Onyeji CO, Pukrittayakamee S, Siqueira AM, Tarning J1, Taylor WRJ1, Valentini G, van Vugt M, Wesche D, Day NPJ, Huang CL, Brugada J, Price RN, White NJ. Factors affecting the electrocardiographic QT interval in malaria: A systematic review and meta-analysis of individual patient data. PLoS Med. 2020 Mar 5;17(3):e1003040. doi: 10.1371/journal.pmed.1003040. eCollection 2020 Mar. PMID: 32134952. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003040
Francis J, Barnes KI, Workman L, Kredo T, Vestergaard LS, Hoglund RM, Byakika-Kibwika P, Lamorde M, Walimbwa S, Chijioke-Nwauche I, Sutherland CJ, Merry C, Scarsi KK, Nyagonde N, Lemnge MM, Khoo SH, Bygbjerg IC, Parikh S, Aweeka FT, Tarning J, Denti P. Drug-drug Interactions between Lumefantrine and Commonly-used Antiretroviral Treatment: An Individual Participant Data Population Pharmacokinetic Meta-Analysis. Antimicrob Agents Chemother. 2020 Feb 18. pii: AAC.02394-19. doi: 10.1128/AAC.02394-19. PMID: 32071050. https://aac.asm.org/content/early/2020/02/11/AAC.02394-19/article-info?versioned=true
Robert Morrell, Karen Barnes, Freedom Gumedze, Hassan Sadiq & Max Price 2020 Misrepresentation of research on academic promotions at the University of Cape Town, Cogent Social Sciences, 6:1, 1728949 https://doi.org/10.1080/23311886.2020.17289
Sinxadi P, Donini C, Johnstone H, Langdon G, Wiesner L, Allen E, Duparc S, Chalon S, McCarthy JS, Lorch U, Chibale K, Möhrle J, Barnes KI. Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 in Healthy Volunteers. Antimicrob Agents Chemother. 2020 Jan 13. pii: AAC.01896-19. DOI: 10.1128/AAC.01896-19. PMID: 31932368 https://aac.asm.org/content/early/2020/01/08/AAC.01896-19/article-info?versioned=true
2019
Sinxadi P, Donini C, Johnstone H, Langdon G, Wiesner L, Allen E, Duparc S, Chalon S, McCarthy JS, Lorch U, Chibale K, Möhrle J, Barnes KI. Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 in Healthy Volunteers. doi: 10.1128/AAC.01896-19. Print 2020 Mar 24.
Barnes KI, Canario JA, Vernekar SS, Goudar SS, Espinal R, Merson L,Cheah YP. Equitable data sharing: challenges and suggestions for ways forward. Latest published: 12 Nov 2019, 4:172. doi.org/10.12688/wellcomeopenres.15425.1
Raman J, Kagoro FM, Mabuza A, Malatje G, Reid A, Frean J, Barnes KI. Absence of kelch13 artemisinin resistance markers but strong selection for lumefantrine-tolerance molecular markers following 18 years of artemisinin-based combination therapy use in Mpumalanga Province, South Africa. Pubmed Central. 2019. 12
Banda CG, Barnes KI, Maartens G. Interpretation of Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine. 2019. 2.
Chotsiri P, Denoeud-Ndam L, Baudin E, Guindo O, Diawara H, Attaher O, Smit M, Guerin PJ, Doumbo OK, Wiesner L, Barnes KI, Hoglund RM, Dicko A, Etard JF, Tarning J. Severe acute malnutrition results in lower lumefantrine exposure in children treated with artemether-lumefantrine for uncomplicated malaria. 2019; Pages 32
Raman J, Allen E, Workman L, Mabuza A, Swanepoel H, Malatje G, Frean J, Weisner L, Barnes KI. Safety and tolerability of single low-dose primaquine in a low-intensity transmission area in South Africa: an open-label, randomized controlled trial. Malaria Journal Biomed Central 2019. Pages 13
Humphreys GS, Tinto H, Barnes KI. Strength in Numbers: The WWARN Case Study of Purpose- Driven Data sharing. Am J Trop Med Hyg. 2019 Jan;100(1):13-15. doi: 10.4269/ajtmh.18-0649. Pages 3
Sadiq, Barnes KI, Gumedze F, Price M, Morrell R, "Academic promotions at a South African University: Questions of bias, politics and transformation", Higher Education 2019: 1-20
2018
Allen EN, Chandler CI, Mandimika N, Leisagang C, Barnes K. Eliciting Adverse Effects Data From Participants On Clinical Trials. Cochrane Database Of Systematic Reviews. 2018 Jan 16. doi: 10.1002/14651858. MR000039.pub2. Review.
Taylor WR, Naw HK, Maitland K, Williams TN, Kapulu M, D'Alessandro U, Berkley JA, Bejon P, Okebe J, Achan J, Amambua AN, Affara M, Nwakanma D, van Geertruyden JP, Mavoko M, Lutumba P, Matangila J, Brasseur P, Piola P, Randremanana R, Lasry E, Fanello C, Onyamboko M, Schramm B, Yah Z, Jones J, Fairhurst RM, Diakite M, Malenga G, Molyneux M, Rwagacondo C, Obonyo C, Gadisa E, Aseffa A, Loolpapit M, Henry MC, Dorsey G, John C, Sirima SB, Barnes KI, Kremsner P, Day NP, White NJ, Mukaka M. Single low-dose Primaquine for Blocking Transmission of Plasmodium Falciparum Malaria- A Proposed Model-derived aged-based regimen for Sub-Saharan Africa. 2018 Jan 18;16 (1):11. doi: 10.1186/s12916-017-0990-6.
de Kock M, Tarning J, Workman L, Allen EN, Tekete MM, Djimde AA, Bell DJ, Ward SA, Barnes KI, Denti P. Population Pharmacokinetic Properties Of Sulfadioxine and Pyrimethamine: A Pooled Analysis To Inform Optimal Dosing In African Children With Uncomplicated Malaria. Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01370-17. doi: 10.1128/AAC.01370-17. Print 2018 May.
Kloprogge F, Workman L, Borrmann S, Tékété M, Lefèvre G, Hamed K, Piola P, Ursing J, Kofoed PE, Mårtensson A, Ngasala B, Björkman A, Ashton M, Friberg Hietala S, Aweeka F, Parikh S, Mwai L, Davis TME, Karunajeewa H, Salman S, Checchi F, Fogg C, Newton PN, Mayxay M, Deloron P, Faucher JF, Nosten F, Ashley EA, McGready R, van Vugt M, Proux S, Price RN, Karbwang J, Ezzet F, Bakshi R, Stepniewska K, White NJ, Guerin PJ, Barnes KI, Tarning J. Artemether-Lumefantrine Dosing For Malaria Treatment In Young Children and Pregnant Women: A Pharmacokinetic-pharmacodynamic Meta-analysis. Plos Med. 2018 Jun 12;15(6):e1002579. doi: 10.1371/journal.pmed.1002579. eCollection 2018 Jun.
de Kock M, Tarning J, Workman L, Allen EN, Tekete MM, Djimde AA, Bell DJ, Ward SA, Barnes KI, Denti P. Population Pharmacokinetic Properties of Sulfadoxine and Pyrimethamine: A Pooled Analysis to Inform Optimal Dosing in African Children with Uncomplicated Malaria. Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01370-17. doi: 10.1128/AAC.01370-17. Print 2018 May
Ali AM, Penny MA, Smith TA, Workman L, Sasi P, Adjei GO, Aweeka F, Kiechel JR, Jullien V, Rijken MJ, McGready R, Mwesigwa J, Kristensen K, Stepniewska K, Tarning J, Barnes KI, Denti P; WWARN amodiaquine PK study group. Population Pharmacokinetics Of The Antimalarial Amodiaquine: A Pooled Analysis To Optimize Dosing. Antimicrob Agents Chemother. July 2018; 48 Pages
Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K. UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria. Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00012-18. doi: 10.1128/AAC.00012-18. Print 2018 Sep
Merson L, Guérin PJ, Barnes KI, Ntoumi F, Gae O. Secondary analysis and participation of those at the data source. Merson L, Guérin PJ, Barnes KI, Ntoumi F, Gaye O. Lancet Glob Health 2018 Sep;6(9):e965. doi:S2214-109X(18)30341-3
Ali A, Penny M, Smith T, Workman L, Sasi P, Adjei G, Aweeka F, Kiechel JR, Jullien V, Rijken M, McGready R, Mwesigwa J, Kristensen K, Stepniewska K, Tarning J, Barnes K, Denti P. Population Pharmacokinetics of the Antimalarial Amodiaquine: A Pooled Analysis To Optimize Dosing. Population Pharmacokinetics of the Antimalarial Amodiaquine: A Pooled Analysis to Optimize Dosing". Antimicrob Agents Chemother 2018 Sep 24;62(10). pii: e02193-17 (NB this was included in the previous report as a pre-published manuscript)
Das D, Grais RF, Okiro EA, Stepniewska K, Mansoor R, van der Kam S, Terlouw DJ, Tarning J, Barnes KI, Guerin PJ. Complex interactions between malaria and malnutrition: a systematic literature review. BMC Med 2018 Oct 29;16(1):186
Sadiq H, Barnes KI, Price M, Gumedze F, Morrell RG. Academic promotions at a South African university: questions of bias, politics and transformation. Higher Education 2018 Dec 12
2017
de Kock M, Tarning J, Workman L, Nyunt MM, Adam I, Barnes KI, Denti P. Pharmacokinetics of Sulfadoxine and Pyrimethamine for Intermittent Preventive Treatment of Malaria During Pregnancy and After Delivery. CPT Pharmacometrics Syst Pharmacol. 2017 Jun 9. doi: 10.1002/psp4.12181. [Epub ahead of print]
Hoglund RM, Workman L, …Guerin PJ, White NJ, Barnes KI, Tarning J (2017). Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis. PLoS Med 10;14(1):e1002212.
Gutierrez MM, Pillai GC, Felix S, Romero F, Omondi Onyango K, Owusu-Agyei S, Asante KP, Barnes KI, Sinxadi P, Allen E, Abdulla S, Masimirembwa C, Munyoro M, Yimer G, Gebre-Mariam T, Spector J, Ogutu B. Building Capability for Clinical Pharmacology Research in sub-Saharan Africa. Clin Pharmacol Ther 2017 Apr 5. [Epub ahead of print].
Mandimika N, Barnes KI, Chandler CI, Pace C, Allen EN. Working towards consensus on methods used to elicit participant-reported safety data in uncomplicated malaria clinical drug studies: a Delphi technique study. Malar J 2017, 16(1):52.
2016
Denoeud-Ndam L, Dicko A, Baudin E, Guindo O, Grandesso F, Diawara H, Sissoko S, Sanogo K, Traoré S, Keita S, Barry A, de Smet M, Lasry E, Smit M, Wiesner L, Barnes KI, Djimde AA, Guerin PJ, Grais RF, Doumbo OK, Etard JF. Efficacy of artemether-lumefantrine in relation to drug exposure in children with and without severe acute malnutrition: an open comparative intervention study in Mali and Niger. BMC Med 2016 Oct 24;14(1):167.
Silal SP, Little F, Barnes KI, White LJ (2015). Hitting a Moving Target: A Model for Malaria Elimination in the Presence of Population Movement. PLoS One 21; 10(12):e0144990. Erratum in: PLoS One 2016;11(7):e0159784.
Kredo T, Mauff K, … Maartens G, Cohen K, Barnes KI (2016). The interaction between artemether-lumefantrine and lopinavir/ritonavir-based antiretroviral therapy in HIV-1 infected patients. BMC Infect Dis 16:30.
Allen E, Leisegang C, Furtado T, van Loggerenberg F, Lang T. Blended-learning using The Global Health Network online resources: a pilot study. BMJ Global Health 2017, 2(Suppl 20), A54. Poster presented at the Eighth EDCTP Forum, Lusaka, Zambia. November 2016.
Barnes, K, Guérin, P, Hodel, EM, Humphreys G, Pace C, Banda C, Denti P, Allen E, Lalloo D, Mwapasa V, Terlouw A. The IMPACT project: improving the impact of existing malaria products. BMJ Global Health 2017, 2(Suppl 2), A26. Poster presented at the Eighth EDCTP Forum, Lusaka, Zambia. November 2016.
CDISC Therapeutic Area Data Standards: User Guide for Uncomplicated Malaria. V1.0 2017. https://www.cdisc.org/standards/therapeutic-areas/malaria
WWARN Gametocyte Study Group. Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data. BMC Med 2016, 14(1):79.
2015
Silal SP, Little F, Barnes KI, White LJ. Predicting the impact of border control on malaria transmission: a simulated focal screen and treat campaign. Malaria J 2015; 14: 268.
Rosenkranz B, Reid M, Allen E. Medicines development and regulation in Africa. Journal of Medicines Development Sciences. 2015 vol.1(2): 33–36.
Denoeud-Ndam L, Dicko A, Baudin E, Guindo O, Grandesso F, Sagara I, Lasry E, Palma PP, Parra AM, Stepniewska K, Djimde AA, Barnes KI, Doumbo OK, Etard JF. A multi-center, open-label trial to compare the efficacy and pharmacokinetics of Artemether-Lumefantrine in children with severe acute malnutrition versus children without severe acute malnutrition: study protocol for the MAL-NUT study. BMC Infect Dis 2015; 15: 228.
Kerpel-Fronius S, Rosenkranz B, Allen E, Bass R, Demotes Mainard J, Dodoo A, Dubois DJ, Hela M, Kern S, Massud J, Silva H, Whitty J. Education and training for medicines development, regulation and clinical research in emerging countries. Front. Pharmacol doi: 10.3389/fphar.2015.00
Worldwide Antimalarial Resistance Network (WWARN) AL Dose Impact Study Group. The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data. Lancet Infect Dis 2015; 15(6): 692-702.
WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group. The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data. BMC Medicine 2015; 13: 66. (free article)
2014
Allen EN, Gomes M, Yevoo L, Egesah O, Clerk C, Byamugisha J, Mbonye A, Were E, Mehta U, Atuyambe LM. Influences on participant reporting in the World Health Organisation drugs exposure pregnancy registry: a qualitative study. BMC Health Serv Res 2014; Oct 31, 14(1): 525.
White NJ, Ashley EA, Recht J, Delves MJ, Ruecker A, Smithuis FM, Eziefula AC, Bousema T, Drakeley C, Chotivanich K, Imwong M, Pukrittayakamee S, Prachumsri J, Chu C, Andolina C, Bancone G, Hien TT, Mayxay M, Taylor WR, von Seidlein L, Price RN, Barnes KI, Djimdé A, ter Kuile F, Gosling R, Chen I, Dhorda MJ, Stepniewska K, Guérin P, Woodrow CJ, Dondorp AM, Day NP, Nosten FH. Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malar J 2014 Dec 9; 13: 483. (Free PMC article)
Silal SP, Little F, Barnes KI, White LJ. Towards malaria elimination in Mpumalanga, South Africa: a population-level mathematical modelling approach. Malar J 2014 Aug 3;13:297.
Lourens C, Lindegardh N, Barnes KI, Guerin PJ, Sibley CH, White NJ, Tarning J. Benefits of a pharmacology antimalarial reference standard and proficiency testing program provided by the Worldwide Antimalarial Resistance Network (WWARN). Antimicrob Agents Chemother. 2014; 58(7): 3889-94. (Free PMC article)
Zaloumis SG, Tarning J, Krishna S, Price RN, White NJ, Davis TM, McCaw JM, Olliaro P, Maude RJ, Kremsner P, Dondorp A, Gomes M, Barnes K, Simpson JA. Population pharmacokinetics of intravenous artesunate: a pooled analysis of individual data from patients with severe malaria. CPT Pharmacometrics Syst Pharmacol 2014 Nov 5; 3:e145. (Free PMC article)
2013
Allen EN, Chandler CI, Mandimika N, Pace C, Mehta U, Barnes KI. Evaluating harm associated with anti-malarial drugs: a survey of methods used by clinical researchers to elicit, assess and record participant-reported adverse events and related data. Malar J 2013 Sep 16;12:325. doi: 10.1186/1475-2875-12-325. (Free PMC article)
Allen EN, Chandler CIR,Mandimika N, Barnes KI. Eliciting adverse effects data from participants in clinical trials (protocol). The Cochrane Library 2013; 9.2.
Allen EN, Mushi AK, Massawe IS, Vestergaard LS, Lemnge M, Staedke SG, Mehta U, Barnes KIB, Chandler CIR. How experiences become data: The process of eliciting adverse event, medical history and concomitant medication reports in antimalarial and antiretroviral interaction trials. BMC Med Res Methodol 2013; 13(1): 140. (Free PMC article)
Morris N, Frean J, Baker L, Ukpe IS, Barnes KI, Kruger P, Mabuza A, Raswiswi E, Maharaj R, Blumberg L, Moonasar D. Re-defining the extent of malaria transmission in South Africa: implications for chemoprophylaxis. S Afr Med J 2013 Oct 2;103(11):861-4. doi: 10.7196/samj.7533.
Silal SP, Barnes KI, Kok G, Mabuza A, Little F. Exploring the seasonality of reported treated malaria cases in Mpumalanga, South Africa. PLoS One 2013 Oct 29;8(10):e76640. doi: 10.1371/journal.pone.0076640. eCollection 2013. (Free PMC article)
Upke IS, Moonasar D, Raman J, Barnes KI, Baker L, Blumberg L. Case management of malaria: treatment and chemoprophylaxis. S Afr Med J 2013 Aug 29;103(10 Pt 2):793-8.
Walubo A, Barnes KI, Kwizera E, Greeff O, Rosenkranz B, Maartens G. Clinical pharmacology becomes a specialty in South Africa. S Afr Med J 2013 Jan 9;103(3):150-1.
WorldWide Antimalarial Resistance Network (WWARN) DP Study Group. The effect of dosing regimens on the antimalarial efficacy of dihydroartemisinin-piperaquine: a pooled analysis of individual patient data. PLoS Med 2013 Dec;10(12):e1001564; discussion e1001564. doi: 10.1371/journal.pmed.1001564. Epub 2013 Dec 3. Review. Erratum in: PLoS Med. 2013 Dec;10(12). doi:10.1371/annotation/3db421e4-3e27-4442-8092-2ad1b778f371. (Free PMC article)