CCOAT is a founding member of the WorldWide Antimalarial Resistance Network (WWARN), the primary theme within the Infectious Diseases Data Observatory (IDDO). Our role leading the WWARN Pharmacology Scientific Group and as the Southern African hub is to conduct individual patient data (IDP) data meta-analyses, a method WWARN has pioneered to increase the power for answering questions that would not be possible in individual studies. These meta-analyses underpin the collaborative platform generating innovative resources and reliable evidence to inform the malaria community on the factors affecting the efficacy of antimalarial medicines.

CCOAT has contributed to analyses investigating. In addition, we manage the WWARN Clinical Trials Toolkit, a pathway with a step by step guide for researchers on how to plan, design, execute and interpret malaria clinical trial results, collecting reliable and comprehensive evidence in a standardised format. An important component is the CDISC Malaria Therapeutic User Guide and CDASH compliant CRF, led by CCOAT, that facilitates alignment of electronic acquisition, exchange, submission and archiving of clinical malaria data collection, a requirement by the UD FDA and other medicines authorities. Our staff also regulatory contribute to training in antimalarial trial methods and conduct, with a focus on developing the next generation of researchers, showcasing the Toolkit at international meetings.