José Miguel Calderín

Jose holds a Bachelor’s degree in Pharmaceutical Sciences from the University of Havana, Cuba. He joined the research group in February 2023 to undertake his PhD, which focused on applying nonlinear mixed-effects modelling to characterise the pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs used to treat pulmonary tuberculosis and tuberculous meningitis.

As a postdoctoral research fellow, Jose continues to apply PK/PD modelling to support treatment optimisation and clinical research in infectious diseases. He also contributes to the training and co-supervision of PhD students.

Current research projects

• Population PK modelling of first-line tuberculosis drugs in paediatric populations using plasma, venous whole-blood and capillary whole-blood data.
• Translational modelling of anti-tuberculosis drug penetration into cerebrospinal fluid and CNS tissues in preclinical models of tuberculous meningitis.
• PK/PD modelling of antiretroviral drugs.
• Modelling drug–drug interactions between antiretroviral and anti-tuberculosis treatments.
• Model-informed design of clinical trials in infectious diseases.

Research interests

• Population PK and PK/PD modelling
• Semi-mechanistic and mechanistic modelling
• Exposure–response analysis
• Drug–drug interactions
• Translational pharmacology and CNS drug penetration

Software

NONMEM, Monolix, Berkeley Madonna, R, Pharmpy and PharmR