2023
Latiş S, Marschner C, Baumgartner J, Prince S, Biswas S, Chakraborty S, Garcia KG, Heeren RMA, Van Nuffel S, Blom B (2023) Synthesis and in vitro anticancer studies of arene ruthenium(II) and arene osmium(II) complexes bearing arsine and stibine co-ligands on breast cancer cell-lines, Journal of Organometallic Chemistry, https://doi.org/10.1016/j.jorganchem.2023.122891.
Golding TM, Omondi RO, Biswas S, Chakraborty S, Prince S, Smith G (2023) Quinolyl-based PGM metallarectangles: Antiproliferative activity, DNA and BSA protein interactions and a molecular docking perspective, ChemBioChem, http://dx.doi.org/10.1002/cbic.202300271.
Higgins G, Higgins F, Peres J, Lang DM, Abdalrahman T, Zaman MH, Prince S, Franz T (2023) Intracellular mechanics and TBX3 expression jointly dictate the spreading mode of melanoma cells in 3D environments, Experimental Cell Research, 428 (2023) 113633.
Manicum A-LE, Louis H, Mathias GE, Agwamba EC, Malan FP, Unimuke TO, Nzondomyo WJ, Sithole SA, Biswas S, Prince S, (2023) Single crystal investigation, spectroscopic, DFT studies, and in-silico molecular docking of the anticancer activities of acetylacetone coordinated Re(I) tricarbonyl complexes, Inorganica Chimica Acta, https://doi.org/10.1016/j.ica.2022.121335.
van Niekerk A, Blanckenberg A, Kimani S, Chakraborty S, Prince S, Chellan P, Mapolie S (2023) Mechanistic insights into the anti-cancer activity of the PEGylated binuclear palladacycle, BTC2, against triple-negative breast cancer, Journal of Inorganic Biochemistry, https://doi.org/10.1016/j.jinorgbio.2023.112191.
2022
Khan SF, Burmeister CA, Scott DJ, Sinkala M, Ramburan A, Wu H-T, Schäfer G, Katz AA, Prince S (2022) TBX3 promotes cervical cancer proliferation and migration via HPV E6 and E7 signaling, Molecular Cancer Research, MCR-22-0598, https://doi.org/10.1158/1541-7786.MCR-22-0598.
Moherane L, Alexander OT, Schutte-Smith M, Biswas S, Prince S, Visser HG, Manicum L (2022) Polypyridyl coordinated rhenium(I) tricarbonyl complexes as model devices for cancer diagnosis and treatment, Polyhedron, Volume 228, 1 December 2022, 116178, https://doi.org/10.1016/j.poly.2022.116178.
Msimango N, Welsh A, Prince S, Smith G (2022) Synthesis and anticancer evaluation of trinuclear N^N quinolinyl-benzimidazole-based PGM complexes, Inorganic Chemistry Communications, https://doi.org/10.1016/j.inoche.2022.109840.
Harrison V, Khan SF, Damerell V, Bleloch J, ArulJothi KN, Sinkala M, Lennard K, Mulder N, Calder B, Blackburn J, Prince S (2022) Strongylopus grayii tadpole blastema extract exerts cytotoxic effects on embryonal rhabdomyosarcoma cells, In Vitro Cellular & Developmental Biology – Animal, https://doi.org/10.1007/s11626-022-00714-6.
Burmeister CA, Khan SF, Schäfer G, Mbatani N, Adams T, Moodley J, Prince S (2022) Cervical cancer therapies: current challenges and future perspectives, Tumour Virus Research, https://doi.org/10.1016/j.tvr.2022.200238.
Neumann-Mufweba A, Kimani S, Khan SF, Chibale K, Prince S (2022) The diaryl-imidazopyridazine anti-plasmodial compound, MMV652103, exhibits anti-breast cancer activity, EXCLI, Experimental and Clinical Sciences, https://www.excli.de/index.php/excli/article/view/4323.
Damerell V, Ambele MA, Salisbury S, Neumann-Mufweba A, Durandt C, Pepper MS, Prince S (2022) The c-Myc/TBX3 axis promotes cellular transformation of sarcoma-initiating cells, Frontiers in oncology, https://doi.org/10.3389/fonc.2021.801691.
2021
Willmer T, Damerell V, Smyly S, Sims D, du Toit M, Ncube S, Sinkala M, Govender D, Sturrock E, Blackburn JM, Prince S (2021) Targeting the oncogenic TBX3:nucleolin complex to treat multiple sarcoma subtypes, American Journal of Cancer, PMID: 34873487.
Welsh A, Mbaba M, Prince S, Smith G (2021) Synthesis, molecular modeling and preliminary anticancer evaluation of 2-ferrocenylbenzimidazole metallofragments, Journal of Molecular Structure, https://doi.org/10.1016/j.molstruc.2021.131122.
Damerell V, Pepper MS, Prince S (2021) The molecular mechanisms underpinning sarcomagenesis and implications for current and future therapy, Signal Transduction and Targeted Therapy, https://doi.org/10.1038/s41392-021-00647-8.
Kimani S, Chakraborty S, Irene I, de la Mare J, Edkins A, du Toit A, Loos B, Blanckenberg A, Van Niekerk A, Costa-Lotufo LV, KN A-J, Mapolie S, Prince S (2021) The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity, Biochemical Pharmacology, https://doi.org/10.1016/j.bcp.2021.114598.
Peres J, Damerell V, Chauhan J, Popovic A, Desprez P-Y, Galibert M-D, Goding CR, Prince S (2021) TBX3 promotes melanoma migration by transcriptional activation of ID1 which sequesters MITF to repress E-cadherin, Journal of Investigative Dermatology, 141, 9, 2250-2260.e2, https://doi.org/10.1016/j.jid.2021.02.740.
Adegoke AM, Prince S, Odunola OA (2021) Cytotoxic and antiproliferative properties of methanol extract of the stem bark of Adansonia digitata LINN. (MESBAD) in breast cancer cells, Afr. J. Biomed. Res. Vol. 24 (January 2021); 123- 128.
Omoruyi SI, Jardine A, Prince S (2021) Response to letter to the Editor: The therapeutic strategy of drug re‑positioning to induce autophagic cell death in brain malignancy, Apoptosis, 26(1), 2-3; https://doi.org/10.1007/s10495-020-01646-w.
2020
Hendricks R, Hofmann E, Peres J, Prince S, Bezuidenhout D (2020) In vivo tendon formation using a novel device for eliciting tongue-base advancement in the management of obstructive sleep apnoea (OSA), Journal of Biomedical Materials Research: Part B - Applied Biomaterials, DOI: 10.1002/jbm.b.34765.
Hunter E, Stander M, Kossmann J, Chakraborty S, Prince S, Peters S, Loedolff B (2020) The identification of a cannabinoid-like compound (adrenoyl-EA), in the flowers of a South African medicinal plant (Leonotis leonurus), BMC Research Notes, 13:522 https://doi.org/10.1186/s13104-020-05372-z.
Mohamed L, Chakraborty S, KN AJ, Mbasa L, Sayah K, Costa-Lotufo LV, Jardine A, Prince S (2020) Galenia africana plant extract exhibits cytotoxicity in breast cancer cells by inducing multiple programmed cell death pathways, Saudi Pharmaceutical Journal, https://doi.org/10.1016/j.jsps.2020.08.004.
Higgins G, Peres J, Abdalrahman T, Zaman MH, Lang DM, Prince S and Franz T (2020) Cytoskeletal tubulin competes with actin to increase deformability of metastatic melanoma cells, Experimental Cell Research, 394 (2020) 112154 https://authors.elsevier.com/c/1bKSh3Im5PYkI.
Aldeghi N, Romano D, Marschner C, Biswas S, Chakraborty S, Prince S, Ngubane S, Blom B (2021) Facile Entry to Germanate and Stannate Complexes [(η6-Arene)RuCl(η2-dppm)]+[ECl3]- (E = Ge, Sn) As Potent Anti-Cancer Agents, Journal of Organometallic Chemistry, 121214;https://doi.org/10.1016/j.jorganchem.2020.121214.
Sims D, Maranyane HM, Damerell V, Govender D, Isaacs AW, Peres J, Prince S (2020) The c-Myc/AKT1/TBX3 axis is important to target in the treatment of embryonal rhabdomyosarcoma, Cancers, 12, 501; doi:10.3390/cancers12020501.
Willard K, Laguette MN, Alves de Souza Rios L, D’Alton C, Nel M, Prince S, Collins M, September AV (2020) Altered expression of proteoglycan, collagen and growth factor genes in a TGF-β1 stimulated genetic risk model for musculoskeletal soft tissue injuries, Journal of Science and Medicine in Sport, https://doi.org/10.1016/j.jsams.2020.02.007.
Omoruyi SI, Ekpo OE, Semenya DM, Jardine A, Prince S (2020) Exploitation of a novel phenothiazine derivative for its anti-cancer activities in malignant glioblastoma, Apoptosis, 25(3), 261-274. DOI: 10.1007/s10495-020-01594-5.
2019
Khan SF, Damerell V, Omar R, Du Toit M, Khan M, Maranyane H, Mlaza M, Bleloch J, Sahm BDB, Peres J, KN A, Prince S, 2019, The roles and regulation of TBX3 in development and disease, Gene, 726:144223| DOI: 10.1016/j.gene.2019.144223.
Omar R, Cooper A, Maranyane HM, Zerbini L, Prince S, 2019, COL1A2 is a bona fide TBX3 target that mediates its impact on fibrosarcoma and chondrosarcoma cell migration, Cancer Letters, 459:227-239| DOI: 10.1016/j.canlet.2019.06.004
Berg C, Chari S, Jurgaityte K, Laurora A, Naldony M, Pope F, Romano D, Medupe T, Prince S, Ngubane S, Blom B, 2019, Modulation of the solubility properties of arene ruthenium complexes bearing stannyl ligands as potential anti-cancer agents, Journal of Organometallic Chemistry, 891:12-19| DOI: 10.1016/j.jorganchem.2019.04.002.
Nel M, Prince S, Heckmann J, 2019, Profiling of patient-specific myocytes identifies altered gene expression in the ophthalmoplegic subphenotype of myasthenia gravis. Orphanet Journal of Rare Diseases, 14:24|DOI: 10.1186/s13023-019-1003-y.
Bleloch J, du Toit A, Gibhard L, Kimani S, Ballim R, Lee M, Blanckenberg A, Mapolie D, Wiesner L, Loos B, Prince S, 2019, The palladacycle complex AJ-5 induces apoptotic cell death while reducing autophagic flux in rhabdomyosarcoma cells, Cell Death Discovery, 5:60| DOI: 10.1038/s41420-019-0139-9.
2018
Jacobs B-A, Chetty A, Horsnell W, Schäfer G, Prince S, Smith KA, 2018 Hookworm exposure decreases the migration and human papillomavirus internalisation of cervical cancer cells. Scientific Reports, 8:11547 | DOI:10.1038/s41598-018-30058-9
Cassells I, Stringer T, Hutton A, Prince S, Smith Greg, 2018 Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions. Journal of Biological Inorganic Chemistry, 23:763–774. https://doi.org/10.1007/s00775-018-1567-3
Davis T, van Niekerk G, Peres J, Prince S, Loos B, Engelbrecht A-M, 2018 Doxorubicin resistance in breast cancer: A novel role for the human protein AHNAK. Biochemical Pharmacology, 148:174-183. DOI: 10.1016/j.bcp.2018.01.012
Jivan R, Peres J, Damelin LH, Wadee R, Veale RB, Prince S, Mavri-Damelin D, 2018 Disulfiram with or without metformin inhibits oesophageal squamous cell carcinoma in vivo. Cancer Letters, 417:1-10. https://doi.org/10.1016/j.canlet.2017.12.026
Zhu B, Chen S, Wang H, Yin C, Han C, Peng C, Liu Z-Q, Wan L, Zhang X, Zhang J, Lian C, Ma P, Xu X, Xu Z-X, Prince S, Wang T, Gao X, Shi Y, Dali L, Liu M, Wei W, Wei Z, Pan J, Wang Y, Xuan Z, Hess J, Hayward N, Goding C, Chen X, Zhou J , Cui R, 2018 The protective role of DOT1L in UV-induced melanomagenesis. Nature Communications, 9:259. DOI: 10.1038/s41467-017-02687-7
2017
Nel M, Buys J-M, Wearne N, Botha FCJ, Prince S, Heckmann J, 2017 The functionality of African-specific variants in the TGFB1 regulatory region and their potential role in HIVAN. Clinical and Experimental Nephrology, https://doi.org/10.1007/s10157-017-1516-4
Blanckenberg A, van Niekerk A, Aliwaini S, Kimani SW, Neumann A, Prince S, Mapolie SF, 2017 Preparation, characterization and evaluation of novel 1,3,5-triaza-7-phosphaadamantane (PTA)-based palladacycles as anti-cancer agents. Journal of Organometallic Chemistry, 851:68-78. https://doi.org/10.1016/j.jorganchem.2017.09.005
Peres J, Maliepaard EM, Rambow F, Larue L, Prince S, 2017 Replacement of the tumour suppressor, miR-137, inhibits malignant melanoma migration by targetting the TBX3 transcription factor. Cancer Letters, DOI: 10.1016/j.canlet.2017.07.018.
Mynhardt C, Damelin LH, Jivan R, Peres J, Prince S, Veale RB and Mavri-Damelin D, 2017 Metformin-induced alterations in nucleotide metabolism cause 5-fluorouracil resistance but gemcitabine susceptibility in oesophageal squamous cell carcinoma. Journal of Cellular Biochemistry, DOI:10.1002/jcb.26291.
Matsheku A, Chen M, Jordaan S, Prince S, Smith G, Makhubela B, 2017 Acridine-containing RuII, OsII, RhIII and IrIII Half-Sandwich Complexes: Synthesis, Structure and Antiproliferative Activity. Applied Organometallic Chemistry, DOI:10.1002/aoc.3852.
Willmer T, Cooper A, Peres J, Omar R, Prince S, 2017 The T-Box transcription factor 3 in development and cancer.BioScience Trends, DOI: http://doi.org/10.5582/bst.2017.01043.
Bleloch JS, Ballim RD, Kimani S, Parkes J, Panieri E, Willmer T, Prince S, 2017 Managing sarcoma: Where have we come from and where are we going? Therapeutic Advances in Medical Oncology, In press.
2016
Klionsky D et al., 2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).AUTOPHAGY, 12:1, 1–222. http://dx.doi.org/10.1080/15548627.2015.1100356.
MK H, Prince S, Mohan AM, Krishnan KV, Arikketh D, 2016 Involvement of Notch4 in promoting metastasis in human oral squamous cell carcinoma. Life Sciences 156, 38-46.
Willmer T, Hare S, Peres J, Prince S, 2016 The T-box transcription factor TBX3 drives proliferation by direct repression of the p21WAF1 cyclin-dependent kinase inhibitor. Cell Division 11:6 DOI 10.1186/s13008-016-0019-0 URL:http://www.celldiv.com/content/11/1/6.
Aliwaini S, Bleloch J, Kimani S, Prince S, 2016 Induction of autophagy and apoptosis in melanoma treated with palladacycle complexes. Elsevier Publishing Company nine-volume series discussing AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging Vol 10 edited by M.A. Hayat (Invited).
Willmer T, Cooper A, Sims D, Govender D, Prince S, 2016 The T-box transcription factor 3 is a promising biomarker and a key regulator of the oncogenic phenotype of a diverse range of sarcoma subtypes. Oncogenesis 5, e199; doi:10.1038/oncsis.2016.11.
2015
Nel M, Buys J-M, Rautenbach R, Mowla S, Prince S, Heckmann JM, 2015 The African−387 C>T TGFB1 variant is functional and associates with the ophthalmoplegic complication in juvenile myasthenia gravis. Journal of Human Genetics, (3 December 2015) DOI:10.1038/jhg.2015.146
Willmer T, Peres J, Mowla S, Abrahams A, Prince S, 2015 The T-Box factor TBX3 is important in S-phase and is regulated by c-Myc and cyclin ACDK2. Cell Cycle, 14:19, 3173-3183. DOI: 10.1080/15384101.2015.1080398.
Prince S, Mapolie S, Blanckenberg A, 2015 Palladium-Based Anti-Cancer Therapeutics. Encyclopedia of Cancer, DOI 10.1007/978-3-642-27841-9_7085-1 (Invited)
Aliwaini S, Peres J, Kröger WL, Blanckenberg A, de la Mare J, Edkins AL, Mapolie S, Prince S, 2015 The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells. Cancer Letters, 357, 206-218. doi:10.1016/j.canlet.2014.11.027.
Peres J, Mowla S, Prince S, 2015 The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis.Oncotarget, 6 (3), 1821-1833.
2014
Li J, Ballim RD, Rodriguez M, Cui R, Goding CR, Teng H, Prince S, 2014 The Anti-proliferative Function of the TGF-β1 Signalling Pathway Involves the Repression of the Oncogenic TBX2 by its Homologue TBX3. Journal of Biological Chemistry, 289, 35633-35643 DOI:10.1074/jbc.M114.596411.
Wansleben S, Peres J, Hare S, Goding CR, Prince S, 2014 T-box transcription factors in cancer biology. BBA - Reviews on Cancer, 1846, 380-391. doi:10.1016/j.bbcan.2014.08.004
Bouafia A, Corre S, Gilot D, Mouchet N, Prince S, Galibert M-D, 2014 p53 requires the stress sensor USF1 to direct appropriate cell fate decisions. PLoS Genetics, 2014; 10(5):e1004309.
Auret J, Abrahams A, Prince S, Heckmann JM, 2014 The Effects of Prednisone and Steroid-sparing agents on Decay Accelerating Factor (CD55) expression: implications in Myasthenia Gravis Neuromuscular Disorders. Neuromuscular Disorders, 24, 499-508 DOI: 0.1016/j.nmd.2014.02.010.
2013
Peres J, Prince S, 2013 The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion.Molecular cancer, 12:117.DOI: 10.1186/1476-4598-12-117 URL: http://www.molecular-cancer.com/content/12/1/117.
Aliwaini S, Blanckenberg A, Swarts AJ, Mapolie S, Prince S, 2013 A novel binuclear palladacycle complex inhibits melanoma growth in vitro and in vivo through apoptosis and autophagy. Biochemical Pharmacology 86, 1650–1663.
Wansleben S, Davis E, Peres J, Prince S, 2013 A novel role for the anti-senescence factor TBX2 in DNA repair and cisplatin resistance. Cell Death and Disease 4, e846 doi:10.1038/cddis.2013.365.
Li J, Weinberg MS, Zerbini L, Prince S, 2013 The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signalling pathway. Molecular Biology of the Cell, 24(22):3569-76. doi: 10.1091/mbc.E13-05-0273. Epub 2013 Sep 11. www.molbiolcell.org/content/early/2013/09/09/mbc.E13-05-0273.full.pdf.
Ballim RD, Prince S, 2013 TBX3 (T-box 3). Atlas Genet Cytogenet Oncol Haematol. URL : http://AtlasGeneticsOncology.org/Genes/TBX3ID42486ch12q24.html Atlas of Genetics and Cytogenetics in Oncology and Haematology (Invited)
2012
Abrahams Y, Laguette M-J, Prince S, Collins M, 2012 Polymorphisms within the COL5A1 3’-UTR that alters mRNA structure and the MIR608 gene are associated with Achilles tendinopathy. Annals of Human Genetics, 77(3):204-214.
Ballim RD, Mendelsohn C, Papaioannou VE, Prince S, 2012 The ulnar-mammary syndrome gene, Tbx3, is a direct target of the retinoic acid signaling pathway, which regulates its expression during mouse limb development. Molecular Biology of the Cell, 23:2362-2372.
Baron Y, Corre S, Mouchet N, Vaulont S, Prince S, Galibert M-D, 2012 USF-1 Is Critical for Maintaining Genome Integrity in Response to UV-Induced DNA Photolesions. PLoS Genetics, 8(1):e1002470.
2011
Smith J, Mowla S, Prince S, 2011 Basal Transcription of the human TBX3 gene, a key developmental regulator which is overexpressed in several cancers, requires functional NF-Y and Sp1 sites. Gene, 486(1-2): 41-6.
Laguette M-J, Abrahams Y, Prince S, Collins M, 2011 Sequence Variants within the 3' UTR of the COL5A1 gene alters mRNA stability: Implications for musculoskeletal soft tissue injuries. Matrix Biology, 30(5-6):338-45.
2010
Mowla S, Pinnock R, Leaner V, Goding CR, Prince S, 2010 PMA-induced upregulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration. Biochemical Journal, 433:145-153.
Pandor A, Ramesar R, Prince S, 2010 Cell-Specific Differences in the Processing of the R14W CAIV Mutant Associated With Retinitis Pigmentosa 17. Journal of Cellular Biochemistry, 111:735–741.
Peres J, Davis E, Mowla S, Bennett DC, Li JA, Wansleben S, Prince S, 2010 The Highly Homologous T-Box Transcription Factors, TBX2 and TBX3, Have Distinct Roles in the Oncogenic Process. Genes and Cancer, 1(3):272-282.
Abrahams A, Parker MI, Prince S, 2010 The T-box transcription factor Tbx2: It's role in development and possible implication in cancer. IUBMB Life, 62(2): 92–102.
Heckmann J, Uwimpuhwe H, Ballo R, Kaur M, Bajic VB, Prince S, 2010 A functional SNP in the regulatory region of the decay-accelerating factor gene associates with extraocular muscle pareses in myasthenia gravis. Genes and Immunity, 11(1): 1 – 10.
2009
Teng H, Ballim RD, Mowla S, Prince S, 2009 Phosphorylation of histone H3 by Protein Kinase C signalling plays a critical role in the regulation of the developmentally important TBX2 gene. Journal of Biological Chemistry, 284:26368-26376.
2008
Davis E, Teng H, Bilican B, Parker MI, Liu B, Carriera S, Goding C, Prince S, 2008 Ectopic TBX2 expression results in polyploidy and cisplatin resistance. Oncogene, 27, 976–984.
Abrahams A, Mowla S, Parker MI, Goding C, Prince S, 2008 UV-mediated Regulation of the Anti-senescence Factor Tbx2.Journal of Biological Chemistry, 283(4), 2223-2230.
Teng H, Parker MI, Prince S, 2008 Functional characterization of cis-acting elements involved in basal transcription of the human Tbx2 gene: A new insight into the role of Sp1 in transcriptional regulation. Gene, 423(1): 8-13.
2007
Teng H, Davis E, Abrahams A, Mowla S, Parker MI, Prince S, 2007 A role for Tbx2 in the regulation of the a2(1) collagen gene in human fibroblasts. Journal of Cellular Biochemistry, 102(3), 618-625.
2004
Prince S, Carreira S, Vans K, Abrahams A, Goding C, 2004 Tbx2 directly represses the expression of the p21WAF1 cyclin-dependent kinase inhibitor. Cancer Research, 64, 1669-1674.