Dr Simon Mendelsohn - PhD in Clinical Science and Immunology – graduated in December 2022

Clinical predictors of pulmonary tuberculosis among South African adults with HIV

Simon C. Mendelsohn, Andrew Fiore-Gartland, Denis Awany, Humphrey Mulenga, Stanley Kimbung Mbandi, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Thomas J. Scriba, Mark Hatherill, the CORTIS-HR Study Team

EClinicalMedicine. 2022 Mar; 45: 101328. Published online 2022 Mar 5. doi: 10.1016/j.eclinm.2022.101328

PMCID: PMC8902614

 

Meeting report: Virtual Global Forum on Tuberculosis Vaccines, 20–22 April 2021

Sara Suliman, Puck T. Pelzer, Moagi Shaku, Virginie Rozot, Simon C. Mendelsohn

Vaccine. 2021 Dec 8; 39(50): 7223–7229. Published online 2021 Sep 15. doi: 10.1016/j.vaccine.2021.08.094

PMCID: PMC8441545

 

Host blood transcriptomic biomarkers of tuberculosis disease in people living with HIV: a systematic review protocol

Simon C Mendelsohn, Humphrey Mulenga, Stanley Kimbung Mbandi, Fatoumatta Darboe, Mary Shelton, Thomas J Scriba, Mark Hatherill

BMJ Open. 2021; 11(8): e048623. Published online 2021 Aug 5. doi: 10.1136/bmjopen-2021-048623

PMCID: PMC8344288

 

Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diagnostic and prognostic accuracy study

Simon C Mendelsohn, Andrew Fiore-Gartland, Adam Penn-Nicholson, Humphrey Mulenga, Stanley Kimbung Mbandi, Bhavesh Borate, Katie Hadley, Chris Hikuam, Munyaradzi Musvosvi, Nicole Bilek, Mzwandile Erasmus, Lungisa Jaxa, Rodney Raphela, Onke Nombida, Masooda Kaskar, Tom Sumner, Richard G White, Craig Innes, William Brumskine, Andriëtte Hiemstra, Stephanus T Malherbe, Razia Hassan-Moosa, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Thomas J Scriba, Mark Hatherill, CORTIS-HR Study Team

Lancet Glob Health. 2021 Jun; 9(6): e841–e853. Published online 2021 Apr 13. doi: 10.1016/S2214-109X(21)00045-0

PMCID: PMC8131200

 

Prospective multicentre head-to-head validation of host blood transcriptomic biomarkers for pulmonary tuberculosis by real-time PCR

Simon C. Mendelsohn, Stanley Kimbung Mbandi, Andrew Fiore-Gartland, Adam Penn-Nicholson, Munyaradzi Musvosvi, Humphrey Mulenga, Michelle Fisher, Katie Hadley, Mzwandile Erasmus, Onke Nombida, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Mark Hatherill, Thomas J. Scriba

Commun Med (Lond) 2022; 2: 26. Published online 2022 Mar 10. doi: 10.1038/s43856-022-00086-8

PMCID: PMC8954216

 

RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

Adam Penn-Nicholson, Stanley Kimbung Mbandi, Ethan Thompson, Simon C. Mendelsohn, Sara Suliman, Novel N. Chegou, Stephanus T. Malherbe, Fatoumatta Darboe, Mzwandile Erasmus, Willem A. Hanekom, Nicole Bilek, Michelle Fisher, Stefan H. E. Kaufmann, Jill Winter, Melissa Murphy, Robin Wood, Carl Morrow, Ildiko Van Rhijn, Branch Moody, Megan Murray, Bruno B. Andrade, Timothy R. Sterling, Jayne Sutherland, Kogieleum Naidoo, Nesri Padayatchi, Gerhard Walzl, Mark Hatherill, Daniel Zak, Thomas J. Scriba, The Adolescent Cohort Study team, The GC6-74 Consortium, The SATVI Clinical and Laboratory Team, The ScreenTB Consortium, The AE-TBC Consortium, The RePORT Brazil Team, Peruvian Household Contacts Cohort Team, The CAPRISA IMPRESS team

Sci Rep. 2020; 10: 8629. Published online 2020 May 25. doi: 10.1038/s41598-020-65043-8

PMCID: PMC7248089

 

Evaluation of a transcriptomic signature of tuberculosis risk in combination with an interferon gamma release assay: A diagnostic test accuracy study

Humphrey Mulenga, Andrew Fiore-Gartland, Simon C. Mendelsohn, Adam Penn-Nicholson, Stanley Kimbung Mbandi, Elisa Nemes, Bhavesh Borate, Munyaradzi Musvosvi, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Thomas J. Scriba, Mark Hatherill, the CORTIS Study Team

EClinicalMedicine. 2022 May; 47: 101396. Published online 2022 Apr 21. doi: 10.1016/j.eclinm.2022.101396

PMCID: PMC9046130

 

The effect of host factors on discriminatory performance of a transcriptomic signature of tuberculosis risk

Humphrey Mulenga, Andrew Fiore-Gartland, Simon C. Mendelsohn, Adam Penn-Nicholson, Stanley Kimbung Mbandi, Bhavesh Borate, Munyaradzi Musvosvi, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Thomas J. Scriba, Mark Hatherill, the CORTIS Study Team

EBioMedicine. 2022 Mar; 77: 103886. Published online 2022 Feb 18. doi: 10.1016/j.ebiom.2022.103886

PMCID: PMC8861653

 

Peripheral Blood Mucosal-Associated Invariant T Cells in Tuberculosis Patients and Healthy Mycobacterium tuberculosis-Exposed Controls

Sara Suliman, Anele Gela, Simon C Mendelsohn, Sarah K Iwany, Kattya Lopez Tamara, Simbarashe Mabwe, Nicole Bilek, Fatoumatta Darboe, Michelle Fisher, Alexandra J Corbett, Lars Kjer-Nielsen, Sidonia B G Eckle, Chuan-Chin Huang, Zibiao Zhang, David M Lewinsohn, James McCluskey, Jamie Rossjohn, Mark Hatherill, Segundo R León, Roger I Calderon, Leonid Lecca, Megan Murray, Thomas J Scriba, Ildiko Van Rhijn, D Branch Moody

J Infect Dis. 2020 Sep 15; 222(6): 995–1007. Published online 2020 Apr 8. doi: 10.1093/infdis/jiaa173

PMCID: PMC7430171

 

Blood transcriptional signatures for tuberculosis testing

Simon C Mendelsohn, Stanley Kimbung Mbandi, Mark Hatherill, Thomas J Scriba

Lancet Respir Med. Author manuscript; available in PMC 2022 Mar 14.

Published in final edited form as: Lancet Respir Med. 2020 Apr; 8(4): 330–331. Published online 2020 Mar 13. doi: 10.1016/S2213-2600(20)30045-X

PMCID: PMC8919958

 

Mycobacterium tuberculosis infection, immune activation, and risk of HIV acquisition

Rachel A. Bender Ignacio, Jessica Long, Aparajita Saha, Felicia K. Nguyen, Lara Joudeh, Ethan Valinetz, Simon C. Mendelsohn, Thomas J. Scriba, Mark Hatherill, Holly Janes, Gavin Churchyard, Susan Buchbinder, Ann Duerr, Javeed A. Shah, Thomas R. Hawn

PLoS One. 2022; 17(5): e0267729. Published online 2022 May 3. doi: 10.1371/journal.pone.0267729

PMCID: PMC9064099

 

The impact of blood transcriptomic biomarker targeted tuberculosis preventive therapy in people living with HIV: a mathematical modelling study

Tom Sumner, Simon C. Mendelsohn, Thomas J. Scriba, Mark Hatherill, Richard G. White

BMC Med. 2021; 19: 252. Published online 2021 Oct 29. doi: 10.1186/s12916-021-02127-w

PMCID: PMC8555196

 

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis

Humphrey Mulenga, Munyaradzi Musvosvi, Simon C. Mendelsohn, Adam Penn-Nicholson, Stanley Kimbung Mbandi, Andrew Fiore-Gartland, Michèle Tameris, Simbarashe Mabwe, Hadn Africa, Nicole Bilek, Fazlin Kafaar, Shabaana A. Khader, Balie Carstens, Katie Hadley, Chris Hikuam, Mzwandile Erasmus, Lungisa Jaxa, Rodney Raphela, Onke Nombida, Masooda Kaskar, Mark P. Nicol, Slindile Mbhele, Judi Van Heerden, Craig Innes, William Brumskine, Andriëtte Hiemstra, Stephanus T. Malherbe, Razia Hassan-Moosa, Gerhard Walzl, Kogieleum Naidoo, Gavin Churchyard, Mark Hatherill, Thomas J. Scriba, the CORTIS Study Team

Am J Respir Crit Care Med. 2021 Dec 15; 204(12): 1463–1472. Published online 2021 Mar 30. doi: 10.1164/rccm.202103-0548OC

PMCID: PMC8865716

 

IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohort

Timothy F. Spracklen, Simon C. Mendelsohn, Claire Butters, Heidi Facey-Thomas, Raphaella Stander, Debbie Abrahams, Mzwandile Erasmus, Richard Baguma, Jonathan Day, Christiaan Scott, Liesl J. Zühlke, George Kassiotis, Thomas J. Scriba, Kate Webb

Front Immunol. 2022; 13: 992022. Published online 2022 Sep 6. doi: 10.3389/fimmu.2022.992022

PMCID: PMC9486543

 

Headway made towards biosignatures for incipient tuberculosis

Thomas J Scriba, Simon C Mendelsohn

Lancet Respir Med. Author manuscript; available in PMC 2022 Mar 10.

Published in final edited form as: Lancet Respir Med. 2020 Apr; 8(4): 328–330. Published online 2020 Jan 17. doi: 10.1016/S2213-2600(19)30355-8

PMCID: PMC8908387

 

Performance of diagnostic and predictive host blood transcriptomic signatures for Tuberculosis disease: A systematic review and meta-analysis

Humphrey Mulenga, Chambrez-Zita Zauchenberger, Erick W. Bunyasi, Stanley Kimbung Mbandi, Simon C. Mendelsohn, Benjamin Kagina, Adam Penn-Nicholson, Thomas J. Scriba, Mark Hatherill

PLoS One. 2020; 15(8): e0237574. Published online 2020 Aug 21. doi: 10.1371/journal.pone.0237574

PMCID: PMC7442252

 

Isoniazid preventive therapy and tuberculosis transcriptional signatures in people with HIV.

Valinetz ED, Matemo D, Gersh JK, Joudeh LL, Mendelsohn SC, Scriba TJ, Hatherill M, Kinuthia J, Wald A, Cangelosi GA, Barnabas RV, Hawn TR, Horne DJ. AIDS.

2022 Aug 1;36(10):1363-1371. doi:10.1097/QAD.0000000000003262

. Epub 2022 May 25. PMID: 35608118


Dr Ashar Dhana - Clinical PhD graduated in March 2023

Tuberculosis screening among ambulatory people living with HIV: a systematic review and individual participant data meta-analysis

Ashar Dhana, Yohhei Hamada, Andre P Kengne, Andrew D Kerkhoff, Molebogeng X Rangaka, Tamara Kredo, Annabel Baddeley, Cecily Miller, Satvinder Singh, Yasmeen Hanifa, Alison D Grant, Katherine Fielding, Dissou Affolabi, Corinne S Merle, Ablo Prudence Wachinou, Christina Yoon, Adithya Cattamanchi, Christopher J Hoffmann, Neil Martinson, Eyongetah Tabenyang Mbu, Melissa S Sander, Taye T Balcha, Sten Skogmar, Byron W P Reeve, Grant Theron, Gcobisa Ndlangalavu, Surbhi Modi, Joseph Cavanaugh, Susan Swindells, Richard E Chaisson, Faiz Ahmad Khan, Andrea A Howard, Robin Wood, Swe Swe Thit, Mar Mar Kyi, Josh Hanson, Paul K Drain, Adrienne E Shapiro, Tendesayi Kufa, Gavin Churchyard, Duc T Nguyen, Edward A Graviss, Stephanie Bjerrum, Isik S Johansen, Jill K Gersh, David J Horne, Sylvia M LaCourse, Haider Abdulrazzaq Abed Al-Darraji, Adeeba Kamarulzaman, Russell R Kempker, Nestani Tukvadze, David A Barr, Graeme Meintjes, Gary Maartens

Lancet Infect Dis. 2022 Apr; 22(4): 507–518. doi: 10.1016/S1473-3099(21)00387-X

Correction in: Lancet Infect Dis. 2023 Apr 17

PMCID: PMC8942858

 

Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis

Ashar Dhana, Yohhei Hamada, Andre P Kengne, Andrew D Kerkhoff, Molebogeng X Rangaka, Tamara Kredo, Annabel Baddeley, Cecily Miller, Ankur Gupta-Wright, Katherine Fielding, Robin Wood, Helena Huerga, Sekai Chenai Mathabire Rücker, Christine Heidebrecht, Douglas Wilson, Stephanie Bjerrum, Isik S Johansen, Swe Swe Thit, Mar Mar Kyi, Josh Hanson, David A Barr, Graeme Meintjes, Gary Maartens

Lancet HIV. 2022 Apr; 9(4): e233–e241. Published online 2022 Mar 23. doi: 10.1016/S2352-3018(22)00002-9

PMCID: PMC8964502

 

Diagnostic accuracy of WHO screening criteria to guide lateral-flow lipoarabinomannan testing among HIV-positive inpatients: A systematic review and individual participant data meta-analysis.

Ashar Dhana, Yohhei Hamada, Andre P Kengne, Andrew D Kerkhoff, Tobias Broger, Claudia M Denkinger, Molebogeng X Rangaka, Ankur Gupta-Wright, Katherine Fielding, Robin Wood, Helena Huerga, Sekai Chenai Mathabire Rücker, Stephanie Bjerrum, Isik S Johansen, Swe Swe Thit, Mar Mar Kyi, Josh Hanson, David A Barr, Graeme Meintjes, Gary Maartens PMID: 35588942

PMCID: PMC10152564  DOI: 10.1016/j.jinf.2022.05.010

 

Early high-dose intravenous corticosteroids rapidly arrest Stevens Johnson syndrome and drug reaction with eosinophilia and systemic symptoms recurrence on drug re-exposure

Rannakoe J. Lehloenya, Thuraya Isaacs, Tonderai Nyika, Ashar Dhana, Lauren Knight, Simon Veenstra, Jonny Peter

J Allergy Clin Immunol Pract. Author manuscript; available in PMC 2021 Feb 10.

Published in final edited form as: J Allergy Clin Immunol Pract. 2021 Jan; 9(1): 582–584.e1. Published online 2020 Aug 22. doi: 10.1016/j.jaip.2020.08.012

Correction in: volume 10 on page 650

PMCID: PMC7874517


Phuti Choshi – Current PhD fellow

Drug hypersensitivity in HIV infection

Jonny Peter, Phuti Choshi, Rannakoe J. Lehloenya

Curr Opin Allergy Clin Immunol. Author manuscript; available in PMC 2020 May 19.

Published in final edited form as: Curr Opin Allergy Clin Immunol. 2019 Aug; 19(4): 272–282. doi: 10.1097/ACI.0000000000000545

PMCID: PMC7236403

 

IFN-γ ELISpot in Severe Cutaneous Adverse Reactions to First-Line Antituberculosis Drugs in an HIV Endemic Setting

Mireille Porter, Phuti Choshi, Sarah Pedretti, Tafadzwa Chimbetete, Rhodine Smith, Graeme Meintjes, Elizabeth Phillips, Rannakoe Lehloenya, Jonny Peter

J Invest Dermatol. Author manuscript; available in PMC 2023 Feb 24.

Published in final edited form as: J Invest Dermatol. 2022 Nov; 142(11): 2920–2928.e5. Published online 2022 Jun 1. doi: 10.1016/j.jid.2022.05.1059

PMCID: PMC9952832

 

Dose Dependent Antimicrobial Cellular Cytotoxicity—Implications for ex vivo Diagnostics

Ana Copaescu, Phuti Choshi, Sarah Pedretti, Effie Mouhtouris, Jonathan Peter, Jason A. Trubiano

Front Pharmacol. 2021; 12: 640012. Published online 2021 Aug 10. doi: 10.3389/fphar.2021.640012

Correction in: Front Pharmacol. 2021; 12: 758192.

PMCID: PMC8383281

 

Corrigendum: Dose Dependent Antimicrobial Cellular Cytotoxicity—Implications for ex vivo Diagnostics

Ana Copaescu, Phuti Choshi, Sarah Pedretti, Effie Mouhtouris, Jonathan Peter, Jason A. Trubiano

Front Pharmacol. 2021; 12: 758192. Published online 2021 Sep 2. doi: 10.3389/fphar.2021.758192

Corrects: Front Pharmacol. 2021; 12: 640012.

PMCID: PMC8444416


Dr Zinhle Cindi - PhD - graduated in March 2023

Genetic Associations with Weight Gain among South Africans who Initiated Dolutegravir- and Tenofovir-containing Regimens

Zinhle Cindi, Gary Maartens, Yuki Bradford, Francois Venter, Simiso Sokhela, Nomathemba Chandiwana, David W. Haas, Phumla Sinxadi

J Acquir Immune Defic Syndr. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: J Acquir Immune Defic Syndr. 2021 Jul 1; 87(3): 1002–1009. doi: 10.1097/QAI.0000000000002661

PMCID: PMC8192425

 

Efavirenz Pharmacogenetics and Weight Gain Following Switch to Integrase Inhibitor–Containing Regimens

Michael A Leonard, Zinhle Cindi, Yuki Bradford, Kassem Bourgi, John Koethe, Megan Turner, Jamison Norwood, Beverly Woodward, Husamettin Erdem, Rebecca Basham, Paxton Baker, Peter F Rebeiro, Timothy R Sterling, Todd Hulgan, Eric S Daar, Roy Gulick, Sharon A Riddler, Phumla Sinxadi, Marylyn D Ritchie, David W Haas

Clin Infect Dis. 2021 Oct 1; 73(7): e2153–e2163. Published online 2020 Oct 17. doi: 10.1093/cid/ciaa1219

PMCID: PMC8492125

 

Pharmacogenetics of Dolutegravir Plasma Exposure Among Southern Africans With Human Immunodeficiency Virus.

Cindi Z, Kawuma AN, Maartens G, Bradford Y, Venter F, Sokhela S, Chandiwana N, Wasmann RE, Denti P, Wiesner L, Ritchie MD, Haas DW, Sinxadi P.

J Infect Dis. 2022 Nov 1;226(9):1616-1625. doi: 10.1093/infdis/jiac174

PMID: 35512135

 

Pharmacogenetics of tenofovir clearance among Southern Africans living with HIV.

Cindi Z, Kawuma AN, Maartens G, Bradford Y, Sokhela S, Chandiwana N, Venter WDF, Wasmann RE, Denti P, Wiesner L, Ritchie MD, Haas DW, Sinxadi P.

Pharmacogenet Genomics. 2023 Jun 1;33(4):79-87.

doi: 10.1097/FPC.0000000000000495.

Epub 2023 Mar 6. PMID: 37098852 Clinical Trial.


Dr Mahmoud Abdelwahab - Postdoctoral fellowship completed March 2022

Linezolid Population Pharmacokinetics in South African Adults with Drug-Resistant Tuberculosis

Mahmoud Tareq Abdelwahab, Sean Wasserman, James C. M. Brust, Keertan Dheda, Lubbe Wiesner, Neel R. Gandhi, Robin M. Warren, Frederick A. Sirgel, Graeme Meintjes, Gary Maartens, Paolo Denti

Antimicrob Agents Chemother. 2021 Dec; 65(12): e01381-21. Prepublished online 2021 Sep 20. Published online 2021 Nov 17. doi: 10.1128/AAC.01381-21

PMCID: PMC8597769

 

Linezolid toxicity in patients with drug-resistant tuberculosis: a prospective cohort study

Sean Wasserman, James C. M. Brust, Mahmoud T. Abdelwahab, Francesca Little, Paolo Denti, Lubbe Wiesner, Neel R. Gandhi, Graeme Meintjes, Gary Maartens

J Antimicrob Chemother. 2022 Apr; 77(4): 1146–1154. Published online 2022 Feb 2. doi: 10.1093/jac/dkac019

PMCID: PMC7612559

 

Population Pharmacokinetic Analysis of Rifampicin in Plasma, Cerebrospinal Fluid, and Brain Extracellular Fluid in South African Children with Tuberculous Meningitis.

Abdelgawad N, Tshavhungwe MP, Rohlwink U, McIlleron H, Abdelwahab MT, Wiesner L, Castel S, Steele C, Enslin JN, Thango NS, Denti P, Figaji A.

Antimicrob Agents Chemother. 2023 Mar 16;67(3):e0147422. doi: 10.1128/aac.01474-22

Epub 2023 Feb 23.

PMID: 36815838


Dr Linda Boloko – Current Clinical PhD Fellow

Xpert Ultra testing of blood in severe HIV-associated tuberculosis to detect and measure Mycobacterium tuberculosis blood stream infection: a diagnostic and disease biomarker cohort study

Linda Boloko, Charlotte Schutz, Nomfundo Sibiya, Avuyonke Balfour, Amy Ward, Muki Shey, Mark P Nicol, Rosie Burton, Robert J Wilkinson, Gary Maartens, Graeme Meintjes, David A Barr

Lancet Microbe. 2022 Jul; 3(7): e521–e532. Published online 2022 Jul. doi: 10.1016/S2666-5247(22)00062-3

PMCID: PMC9242865


Avuyonke Balfour – Current PhD Fellow

Functional and Activation Profiles of Mucosal-Associated Invariant T Cells in Patients With Tuberculosis and HIV in a High Endemic Setting

Avuyonke Balfour, Charlotte Schutz, Rene Goliath, Katalin A. Wilkinson, Sumaya Sayed, Bianca Sossen, Jean-Paul Kanyik, Amy Ward, Rhandzu Ndzhukule, Anele Gela, David M. Lewinsohn, Deborah A. Lewinsohn, Graeme Meintjes, Muki Shey

Front Immunol. 2021; 12: 648216. Published online 2021 Mar 22. doi: 10.3389/fimmu.2021.648216

PMCID: PMC8019701


Dr Hygon Mutavhatsindi – postdoctoral fellowship completed March 2023

Escape from recognition of SARS-CoV-2 Beta variant spike epitopes but overall preservation of T cell immunity

Catherine Riou, Roanne Keeton, Thandeka Moyo-Gwete, Tandile Hermanus, Prudence Kgagudi, Richard Baguma, Ziyaad Valley-Omar, Mikhail Smith, Houriiyah Tegally, Deelan Doolabh, Arash Iranzadeh, Lynn Tyers, Hygon Mutavhatsindi, Marius B. Tincho, Ntombi Benede, Gert Marais, Lionel R. Chinhoyi, Mathilda Mennen, Sango Skelem, Elsa du Bruyn, Cari Stek, SA-CIN, Tulio de Oliveira, Carolyn Williamson, Penny L. Moore, Robert J. Wilkinson, Ntobeko A. B. Ntusi, Wendy A. Burgers

Sci Transl Med. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Sci Transl Med. 2022 Feb 9; 14(631): eabj6824. Published online 2022 Feb 9. doi: 10.1126/scitranslmed.abj6824

PMCID: PMC9434381

 

Protocol to quantify and phenotype SARS-CoV-2-specific T cell response using a rapid flow-cytometry-based whole blood assay

Hygon Mutavhatsindi, Catherine Riou

STAR Protoc. 2022 Dec 16; 3(4): 101771. Published online 2022 Sep 26. doi: 10.1016/j.xpro.2022.101771

PMCID: PMC9510067


Tafadzwa Chimbetete – Masters fellowship March 2023, current PhD fellow

HIV-Associated Immune Dysregulation in the Skin: A Crucible for Exaggerated Inflammation and Hypersensitivity

Tafadzwa Chimbetete, Chloe Buck, Phuti Choshi, Rose Selim, Sarah Pedretti, Sherrie Jill Divito, Elizabeth Jane Phillips, Rannakoe Lehloenya, Jonny Peter

J Invest Dermatol. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: J Invest Dermatol. 2023 Mar; 143(3): 362–373. Published online 2022 Dec 20. doi: 10.1016/j.jid.2022.07.035

PMCID: PMC9974923

 

IFN-γ ELISpot in Severe Cutaneous Adverse Reactions to First-Line Antituberculosis Drugs in an HIV Endemic Setting

Mireille Porter, Phuti Choshi, Sarah Pedretti, Tafadzwa Chimbetete, Rhodine Smith, Graeme Meintjes, Elizabeth Phillips, Rannakoe Lehloenya, Jonny Peter

J Invest Dermatol. Author manuscript; available in PMC 2023 Feb 24.

Published in final edited form as: J Invest Dermatol. 2022 Nov; 142(11): 2920–2928.e5. Published online 2022 Jun 1. doi: 10.1016/j.jid.2022.05.1059

PMCID: PMC9952832

 

Skin infiltrating T-cell profile of drug reaction with eosinophilia and systemic symptoms (DRESS) reactions among HIV-infected patients

Tafadzwa Chimbetete, Phuti Choshi, Sarah Pedretti, Mireille Porter, Riyaadh Roberts, Rannakoe Lehloenya, Jonathan Peter

Front Med (Lausanne) 2023; 10: 1118527. Published online 2023 May 5. doi: 10.3389/fmed.2023.1118527

PMCID: PMC10196146


Dr Mmamapudi Kubjane – graduated in July 2023

The impact of HIV and tuberculosis interventions on South African adult tuberculosis trends, 1990-2019: a mathematical modeling analysis

Mmamapudi Kubjane, Muhammad Osman, Andrew Boulle, Leigh F. Johnson

Int J Infect Dis. 2022 Sep; 122: 811–819. doi: 10.1016/j.ijid.2022.07.047

PMCID: PMC9439958

 

Drivers of sex differences in the South African adult tuberculosis incidence and mortality trends, 1990-2019.

Kubjane M, Cornell M, Osman M, Boulle A, Johnson LF.

Sci Rep. 2023 Jun 10;13(1):9487.

doi: 10.1038/s41598-023-36432-6.

PMID: 37301904

 

Challenges in estimating HIV prevalence trends and geographical variation in HIV prevalence using antenatal data: Insights from mathematical modelling

Leigh F. Johnson, Mmamapudi Kubjane, Jeffrey W. Eaton

PLoS One. 2020; 15(11): e0242595. Published online 2020 Nov 20. doi: 10.1371/journal.pone.0242595

PMCID: PMC7679018


Raymond Moseki – current PhD fellow

Phenotypic Profile of Mycobacterium tuberculosis-Specific CD4 T-Cell Responses in People With Advanced Human Immunodeficiency Virus Who Develop Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

Moseki RM, Barber DL, Du Bruyn E, Shey M, Van der Plas H, Wilkinson RJ, Meintjes G, Riou C. Open Forum Infect Dis. 2022 Oct 17;10(1):ofac546. doi: 10.1093/ofid/ofac546. eCollection 2023 Jan.

PMID: 36726536


Maxine Höft– current postdoctoral fellow

The immune response to SARS-CoV-2 in people with HIV.

Höft MA, Burgers WA, Riou C.

Cell Mol Immunol. 2023 Oct 11. doi: 10.1038/s41423-023-01087-w. Online ahead of print.

PMID:37821620 Review.

 

Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA.2.86 variant.

Nesamari R, Omondi MA, Baguma R, Höft MA, Ngomti A, Nkayi AA, Besethi AS, Magugu SFJ, Mosala P, Walters A, Clark GM, Mennen M, Skelem S, Adriaanse M, Grifoni A, Sette A, Keeton RS, Ntusi NAB, Riou C, Burgers WA.

Cell Host Microbe. 2024 Jan 10:S1931-3128(23)00498-5. doi: 10.1016/j.chom.2023.12.003. Online ahead of print. PMID: 38211583


Rephaim Mpofu(MMed)-Clinical PhD Fellow

Determinants of early change in serum creatinine after initiation of dolutegravir-based antiretroviral therapy in South Africa.

Mpofu R, Kawuma AN, Wasmann RE, Akpomiemie G, Chandiwana N, Sokhela SM, Moorhouse M, Venter WDF, Denti P, Wiesner L, Post FA, Haas DW, Maartens G, Sinxadi P.Br J Clin Pharmacol. 2024 Feb 8. doi: 10.1111/bcp.16009. Online ahead of print.PMID: 38332460