As a global leader in medical mycology, the MRC CMM tackles critical gaps in understanding and healthcare strategies for fungal infections. 

research1

As a unit of the MRC CMM, based at the University of Cape Town (UCT), the CMM AFRICA Unit is committed to establishing research and training programmes that tackle priority fungal research that is relevant to the African continent. We are dedicated to leading world-class research and training, equipping the next generation of scientists and clinicians with the knowledge and skills to address fungal diseases.

Vision: To position Africa as a global leader in fungal disease research, sustainable innovation and evidence-based public health solutions.

Mission: To advance the understanding of fungal diseases through integrated basic and clinical research, translating discoveries in fungal biology and host–pathogen interactions into improved diagnostics, therapies, and patient outcomes.

Strategic Research Themes

i.   Host/pathogen interactions
ii.  Immune response to fungal infection
iii. Emerging pathogens and antifungal resistance
iv. Disease epidemiology and clinical management; Biomarkers, diagnostics, and therapeutics

Research Agenda

  • Cryptococcosis
  • Pneumocystosis
  • Candidiasis
  • Endemic thermally-dimorphic fungal pathogens (e.g. emergomycosis, histoplasmosis, sporotrichosis, blastomycosis)
  • Co-infections with fungal pathogens
research2

 

The emergence of neuroinvasive Cryptococcus: why eucalyptus-rich regions, especially in Africa, may be facing greater risk 

Irere H, Dangarembizi R, Mukaremera L, Dambuza IM 
Front Cell Infect Microbiology, March 2026

Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival

Torigoe S, Salie S, Keeton R, Aylan B, Appelmelk BJ, Williams DL, Lowman DW...A Höft M, Shoesmith R, Ndengane M, Coussens AK, Willment JA, Gutierrez MG, Hoving JC, Yamasaki S, Brown GD 
Science Immunology, January 2026

Opportunistic fungal infections in Sub-Saharan Africa 

Lucian Duvenage, Emily Ruth Higgitt, Rachael Dangarembizi, J Claire Hoving 
Annual Review of Microbiology, October 2025

 AIDS-related mycoses: advances, challenges, and future directions

Rachael Dangarembizi, Jennifer Claire Hoving, David R Boulware, Arnaldo Lopes Colombo, Nelesh P Govender, Rita Oladele, Vu Quoc Dat, Ilan S Schwartz, Gordon D Brown 
Trends in Microbiology, February 2025

Closed
Metabolic modelling as a powerful tool to identify critical components of Pneumocystis growth medium

Nev OA, Zamaraeva E, De Oliveira R, Ryzhkov I, Duvenage L, Abou-Jaoudé W, Ouattara DA, Hoving JC, Gudelj I, Brown AJP 
PLOS Computational Biology, October 2024

Slicing through the challenge of maintaining Pneumocystis in the laboratory

Nev OA, Duvenage L, Brown AJP, Dangarembizi R, Hoving JC 
mBio, February 2024

The pathogenesis of experimental Emergomycosis in mice 

Maxine A Höft, Lucian Duvenage, Sumayah Salie, Roanne Keeton, Alfred Botha, Ilan S Schwartz, Nelesh P Govender, Gordon D Brown, Jennifer Claire Hoving 
PLOS Neglected Tropical Diseases, January 2024

 Emerging and re-emerging fungal threats in Africa 

Rachael Dangarembizi, Sean Wasserman, Jennifer Claire Hoving 
Parasite Immunology, February 2023

Closed