Funder: Medical Research Council Foundation (UK)

This collaborative project between the Universities of Manchester (UoM) and Cape Town (UCT) seeks to address the lack of basic information about Congenital Heart Disease (CHD) in Africa. Objectives include investigating whether the rate at which CHD occurs is the same in African populations as in Western populations, and whether the range of CHD conditions encountered is similar. The project aims to establish a sustainable CHD research infrastructure at UCT, and to create a model that could be applied in other South African centres and collaborating African countries.

Adult and paediatric patients who attend the UCT CHD clinics are invited to participate in and contribute to a comprehensive clinical database containing information about both themselves and their families. Blood or saliva samples are requested to investigate the role of inherited factors (genes) in causing CHD.

The UK partner group at the UoM guides the genetic investigation of African-derived genes already shown to be important in Western populations. If this foundation project shows that it is feasible to enrol and conduct genetic studies in African CHD patients, future experiments will be designed and conducted to search for particularly African genetic causes of CHD. Studies modelling the abnormal blood flow that occurs in CHD patients using powerful computers will also be carried out to see if patterns that are useful in predicting outcomes for patients can be identified.

The data and resources developed in this project will help African researchers define the most important and feasible research topics for future study in the population they serve. The research emerging from this registry will provide clear signposts on steps that can be taken to address the extremely different outcomes of CHD, now a very treatable condition, between Western and African countries.

PROTEA in the Media

The Heart of the Matter, DRUM,



 PROTEA, A Southern African Multicenter Congenital Heart Disease Registry and Biorepository: Rationale, Design, and Initial Results

 The Partnerships in Congenital Heart Disease in Africa Study (PROTEA): Clinical Characteristics and Genetic Findings from a South African Congenital Heart Disease Cohort (abstract)

 A Patient-Specific CFD Pipeline Using Doppler Echocardiography for Application in Coarctation of the Aorta in a Limited Resource Clinical Context

Join Our Partnership for Children with Heart Disease in Africa

Professional Partnerships

Patient Participation

Revisit the Inaugural PROTEA Workshop

Click here to view photos from day 1 of the Inaugural PROTEA Workshop.

Click here to view photos from day 2 of the Inaugural PROTEA Workshop.

Click here to view photos from the 2019 listen to my heart patient and family event.

Click here to view all recordings from the basic and advanced echo workshops, or view individual presentations below;

Series Presentation Title Presenter(s)
Basic Echo Setting up and switching on Yanita Singh
Basic Echo Ensuring high echo quality: What's easy, what's difficult Will Border
Basic Echo Sequential segmental analysis in echocardiography George Comitis
Basic Echo Basic LV and RV function Barend Fourie
Basic Echo An approach to an ASD Fenny Shidika
Basic Echo The echocardiographic evaluation of "simple" congenital heart disease: Ventricular septal defects Chris Hugo-Hamman
Basic Echo Coarctation of the aorta Jayneel Joshi
Basic Echo Atrio-ventricular septal defects Will Border
Basic Echo Tetralogy of fallot Jayneel Joshi
Basic Echo Simple transposition of the great arteries Harold Pribut
Basic Echo Echocardiography of partial and total anomalous pulmonary venous drainage  George Comitis
Basic Echo Coronary artery anomalies Will Border
Basic Echo Fetal echocardiography: The fundamentals Sonia Barr
Basic Echo ARF versus RHD: Nomenclature matters Craig Sable
Basic Echo Use of TOE in congenital cardiac surgery Justiaan Swanevelder
Advanced Echo Studies of Rheumatic Heart Disease in South Africa and beyond Mark Engel
Advanced Echo RHD in Uganda: Research to clinical practice Twalib Aliku
Advanced Echo Clinical cases and conundrums in RHD Nigel Wilson
Advanced Echo PROTEA: Partnerships in congenital heart disease in Africa Thomas Aldersley
Advanced Echo Genetics of congenital heart disease Gasnat Shaboodien
Advanced Echo Computational fluid dynamics modelling for medical applications Malebogo Ngoepe/Liam Swanson
Advanced Echo CMR in CHD: First principles Hopewell Ntsinjana
Advanced Echo Echocardiography in paediatric cardiomyopathy and myocarditis: The IMHOTEP echo George Comitis
Advanced Echo Assessing the right ventricle Barend Fourie
Advanced Echo Echo assessment of pulmonary hypertension in Eisenmengers Will Border
Advanced Echo Echo assessment of the GUCH patient Blanche Cupido
Advanced Echo Speckle tracking basics John Lawrenson
Advanced Echo Cardio-oncology strain assessment for all? Will Border
Advanced Echo Echocardiography in paediatric HIV Amy Sanyahumbi
Advanced Echo Shock and point of care echo Beyra Rossouw
Advanced Echo Double outlet right ventricle: Echocardiography and the concepts for surgical decision making Craig Sable
Advanced Echo DORV: Lost in translation Andre Brooks
Advanced Echo Innovative teaching concepts in echo Will Border
Advanced Echo Echo approach to heterotaxy Will Border
Advanced Echo Why we need an echo machine in the cath lab John Lawrenson
Advanced Echo CTA in congenital heart disease Hopewell Ntsinjana
Advanced Echo Research think tank: What is needed in CHD research in Africa? Mark Engel/Chris Hugo-Hamman (facilitators)
Advanced Echo Children's HeartLink: Improving access to quality paediatric cardiac care Bistra Zheleva
Advanced Echo Echo quiz: Get prepared for your certificate exam Hopewell Ntsinjana/George Comitis (facilitators)
Advanced Echo Exercise stress echocardiography: Utility in paediatric and adult patients with congenital heart disease Will Border
Advanced Echo Detailed valve assessment in the adult Blanche Cupido
Advanced Echo Burnout and work-life balance among paediatric cardiologists Will Border