Funder: The Newton Fund

IMHOTEP is a pan-African multicentre prospective cohort study with four objectives: (1) to phenotype and classify patients with cardiomyopathy into familial and non-familial disease according to the European Society of Cardiology (ESC) criteria; (2) to conduct genetic studies of causal genes in familial disease, and genetic association studies for susceptibility genes in cases of non-familial disease; (3) to establish the prevalence of myocarditis using CMR and histology at two centres where this capacity exists (Cape Town and Johannesburg); and, (4) to determine the outcome of cardiomyopathy in Africans. This study is likely to yield novel insights into the molecular genetics of cardiomyopathy, the role of myocarditis in the pathogenesis of the disease, as well as the outcome and determinants of morbidity and mortality.