Dr M-J Nancy Laguette
Junior Research Fellow
Research Thrusts
Sport & Exercise related injuries: research is focussed on the molecular mechanisms underpinning the genetic risk of musculoskeletal soft tissue injury
Academic Qualifications
PhD (Medical Cellular Biology)
Positions
- HPALs@UCT Junior Research Fellow
- Australia Awards-Africa collaborative postdoctoral fellow
- Former SAWISE executive committee member: Scholarship portfolio
Research Output
Peer reviewed Publication Number: 12
Google Citations: 353
NRF rating: Y2
Scopus H-index: 6
Google H-index: 7
Google Scholar link or ORCID link
https://scholar.google.com/citations?hl=en&user=mrxJUo4AAAAJ
International and national research collaborations
- Induced tendinopathy model: Drs Samiric, Rio, Docking and Profs Cook, Collins and September
- goING consortium - Consolidation (large, combined cohorts) of genetic association studies concerned with ACL rupture genetic susceptibility research (Global: SA-HOL-SWE-POL-AUS-JPN) led by Profs September and Eynon
- Prof Cieszczyk - Exercise science, performance, and related injuries
- Prof Prince – Cell Biology Division, Dept. of Human Biology, FHS, UCT
- Profs Dandara and Chimusa – Human Genetics Division, Dept. of Clinical Laboratory Sciences, FHS, UCT
- WHO report concerned with Physical activity and People living with HIV led by Profs EV Lambert (UCT) and Leach (UWC)
Recent and noteworthy publications
- Feldmann, D.C., Rahim, M., Suijkerbuijk, M.A.M., Laguette, M.-J.N., Cieszczyk, P., Ficek, K., Huminska-Lisowska, K., Häger, C.K., Stattin, E., Nilsson, K.G., Alvarez-Rumero, J., Eynon, N., Feller, J., Tirosh, O., Posthumus, M., Chimusa, E.R., Collins, M., September, A.V. Investigation of multiple populations highlight VEGFA polymorphisms to modulate anterior cruciate ligament injury. (2021) Journal of Orthopaedic Research. DOI: 10.1002/jor.25192. Article in Press
- Chapter 11 - Epigenetic regulation and musculoskeletal injuries. Laguette M.-J.N., Suijkerbuijk, M.A.M., September, A.V. Editor(s): Stuart M. Raleigh, In Translational Epigenetics, Epigenetics of Exercise and Sports. (2021) Academic Press, 25:235-246. ISBN 9780128206829, DOI:10.1016/B978-0-12-820682-9.00003-7.
- Wojciechowicz, B., Laguette, M.J.N., Sawczuk, M., Humińska-Lisowska, K., Maciejewska-Skrendo, A., Ficek, K., Michałowska-Sawczyn, M., Leońska-Duniec, A., Kaczmarczyk, M., Chycki, J., Trybek, G., September, A.V., Cięszczyk, P. Are KIF6 and APOE polymorphisms associated with power and endurance athletes? (2021) European Journal of Sport Science, 21 (9), pp. 1283-1289. DOI: 10.1080/17461391.2020.1817983. PUBMED ID: 32867607
- Willard, K., Laguette, M.-J.N., Alves de Souza Rios, L., D'Alton, C., Nel, M., Prince, S., Collins, M., September, A.V. Altered expression of proteoglycan, collagen and growth factor genes in a TGF-β1 stimulated genetic risk model for musculoskeletal soft tissue injuries. (2020) Journal of Science and Medicine in Sport, 23 (8), pp. 695-700. Cited 3 times. DOI: 10.1016/j.jsams.2020.02.007. PUBMED ID: 32061523
- Laguette, M.-J.N., Barrow, K., Firfirey, F., Dlamini, S., Saunders, C.J., Dandara, C., Gamieldien, J., Collins, M., September, A.V. Exploring new genetic variants within COL5A1 intron 4-exon 5 region and TGF-β family with risk of anterior cruciate ligament ruptures. (2020) Journal of Orthopaedic Research, 38 (8), pp. 1856-1865. DOI: 10.1002/jor.24585. PUBMED ID: 31922278
- Pastuszak-Lewandoska, D., Domańska-Senderowska, D., Kiszałkiewicz, J., Szmigielska, P., Snochowska, A., Ratkowski, W., Spieszny, M., Klocek, T., Godlewski, P., Cięszczyk, P., Brzeziańska-Lasota, E., September, A.V., Laguette, M.J. Expression levels of selected cytokines and microRNAs in response to vitamin D supplementation in ultra-marathon runners. (2020) European Journal of Sport Science, 20 (2), pp. 219-228. Cited 2 times. DOI: 10.1080/17461391.2019.1635649. PUBMED ID: 31241425
- Lulińska-Kuklik, E., Laguette, M.-J.N., Moska, W., Weber-Rajek, M., Ficek, K., Puchala, R., Cięszczyk, P., Sawczuk, M., September, A.V., Maciejewska-Skrendo, A. Are TNC gene variants associated with anterior cruciate ligament rupture susceptibility? (2019) Journal of Science and Medicine in Sport, 22 (4), pp. 408-412. Cited 4 times. DOI: 10.1016/j.jsams.2018.10.003. PUBMED ID: 30528246
- Domańska-Senderowska, D., Laguette, M.-J.N., Jegier, A., Cieszczyk, P., September, A.V., Brzeziańska-Lasota, E. MicroRNA Profile and Adaptive Response to Exercise Training: A Review. (2019) International Journal of Sports Medicine, 40 (4), pp. 227-235. Cited 29 times. DOI: 10.1055/a-0824-4813. PUBMED ID: 30791082
- Abrahams, Y., Laguette, M.-J., Prince, S., Collins, M. Polymorphisms within the COL5A1 3′-UTR That Alters mRNA Structure and the MIR608 Gene are Associated with Achilles Tendinopathy. (2013) Annals of Human Genetics, 77 (3), pp. 204-214. Cited 62 times. DOI: 10.1111/ahg.12013. PUBMED ID: 23347277
- Laguette, M.-J., Abrahams, Y., Prince, S., Collins, M. Sequence variants within the 3'-UTR of the COL5A1 gene alters mRNA stability: Implications for musculoskeletal soft tissue injuries. (2011) Matrix Biology, 30 (5-6), pp. 338-345. Cited 60 times. DOI: 10.1016/j.matbio.2011.05.001. PUBMED ID: 21609763.
Grants and funding
- Australia Awards – Africa Postdoctoral fellowship 2018: ~450,000 ZAR – includes monthly stipend, mobilisation, flights, lab bench fees and medical insurance.
- International Collaborative Research Project grant 2016 applied with PI: 50,000 ZAR.
- DST-NRF Collaborative Postdoctoral Fellowship (Grant-holder linked) 2015-2017: 255,000 + 50,000 ZAR for lab expenses/annum.
- UCT Conference travel grant for overseas 2016: 10,000 ZAR