Nicki started her research career in molecular genetics at UCT, followed by a Ph D in molecular oncology at the University of London and a postdoctoral fellowship in endocrinology research at UCSF. She continued in medical genomics and bioinformatics as a Principal Investigator at the South African National Bioinformatics Institute, focusing on computational approaches to disease gene identification and the genetics of disease in African populations - developing computational approaches to prioritising candidate aetiological genes from the output of genome-wide analyses; as well as undertaking exome sequencing projects to identify rare aetiological variants in families with inherited diseases. During this time Nicki also addressed ethical issues relating to genomic studies undertaken in African populations. She completed a Masters in Public Health (Epidemiology), and worked in the field of health informatics and data governance at the Centre for Infectious Disease Epidemiology and Research (CIDER), contributing to the development of the Provincial Health Data Centre. She has joined CIDRI-Africa and the Department of Integrative Biomedical Sciences (Computational Biology) as part of the Data Integration platform.