Paper on Myocardial Infarction Research Published
The paper "Studying the influence of hydrogel injections into the infarcted left ventricle using the element-free Galerkin method" by D Legner, S Skatulla, J MBewu, RR Rama, BD Reddy, C Sansour, NH Davies and T Franz was published in the International Journal for Numerical Methods in Biomedical Engineering [full-text].
A strain-invariant-based stored energy function was proposed to account for the passive mechanical behaviour of the myocardium. An additive homogenisation approach was introduced to account for biomaterial injectates in the infarct. This method allows to discriminate between stresses sustained by myocardial tissue and injectate. The numerical framework was developed using an in-house code based on the element-free Galerkin method. The main focus of this study was to investigate the influence of gel injections on the mechanics of the infarcted left ventricle during diastolic filling and systolic isovolumetric (isochoric) contraction. Attention was restricted to the necrotic stage of the infarct. Four different injection types were investigated and compared with healthy and infarct cases.