We offer a comprehensive suite of validated LC-MS/MS assays for the quantitative analysis of drugs and metabolites in various biological matrices. In addition to our existing portfolio, our laboratory has extensive expertise in developing and validating bespoke assays to meet specific client requirements, in compliance with international regulatory standards.

We offer the following validated assays

• Plasma Assays

  Antiretrovirals

  Abacavir Atazanavir Bictegravir Cabotegravir Darunavir Dolutegravir*

  Doravirine Efavirenz* Emtricitabine Lamivudine Lopinavir* Nevirapine*

  Raltegravir Rilpivirine Ritonavir Tenofovir Tenofovir alafenamide Zidovudine

  Antituberculosis drugs (and metabolites)

  Bedaquiline (and N-desmethyl metabolite, M2) Clofazimine Cycloserine Delamanid (and DM-6705) Dexamethasone Ethambutol EthionamideIsoniazid (and acetyl isoniazid) Sutezolid (and sutezolid-M1and sutezolid-M2)

  Kanamycin Levofloxacin Linezolid Moxifloxacin Ofloxacin Pretomanid TBI-223 (and TBI-223 M2

  Pyrazinamide Rifabutin (and 25-desacetyl rifabutin) Rifampicin (and 25-desacetyl rifampicin) Rifapentine (and 25-desacetyl rifapentine) Sulfamethoxazole Trimethoprim

  Other

  4β-hydroxycholesterol Coproporphyrin Piperaquine in plasma

  Lumefantrine (and desbutyl lumefantrine) Metformin

  Medroxyprogesterone (and progesterone) Amlodipine *semi-quantitative analysis only

• Dried blood spots (DBS) Assays

  Antiretrovirals (and metabolites) Tenofovir (and tenofovir diphosphate) Qualitative DBS analysis only Atazanavir Darunavir Dolutegravir Efavirenz Emtricitabine Lamivudine Lopinavir Nevirapine Tenofovir Zidovudine

  Antituberculosis drugs (and metabolites) Bedaquiline (and N-desmethyl metabolite, M2) Clofazimine Levofloxacin Linezolid

  Other Lumefantrine (and desbutyl lumefantrine)

• Cerebrospinal fluid Assays

  Antiretrovirals Efavirenz Emtricitabine Tenofovir

  Antituberculosis drugs (and metabolites) Bedaquiline (and N-desmethyl metabolite, M2) Clofazimine Delamanid (and DM-6705) Isoniazid (and in microdialysate) Levofloxacin Linezolid Pyrazinamide (and in microdialysate) Rifampicin (and in microdialysate) Ethionamide (and in microdialysate)

• Urine Assays

  Antituberculosis drugs (and metabolites)

  • Isoniazid (and acetyl isoniazid)
   

• Breastmilk Assays

  Antituberculosis drugs (and metabolites)

  Bedaquiline (and N-desmethyl metabolite, M2) Clofazimine Delamanid (and DM-6705) EthambutolIsoniazid (and acetyl isoniazid)

  Levofloxacin Linezolid Moxifloxacin Pyrazinamide

  Rifabutin (and 25-desacetyl rifabutin) Rifampicin (and 25-desacetyl rifampicin) Rifapentine (and 25-desacetyl rifapentine) Cabotegravir

• Peripheral blood mononuclear cells (PBMCs) Assays

  Antiretrovirals Efavirenz Lopinavir Ritonavir

  Antituberculosis drugs (and metabolites) Bedaquiline (and N-desmethyl metabolite, M2) Clofazimine

• Lung tissue Assays

  Antituberculosis drugs (and metabolites)

  Bedaquiline (and N-desmethyl metabolite, M2) Clofazimine Delamanid (and DM-6705) Levofloxacin

  Linezolid Moxifloxacin Pretomanid

• Pericardial fluid Assays

  Antituberculosis drugs (and metabolites)

  Ethambutol Isoniazid (and acetyl isoniazid)

  Pyrazinamide Rifampicin (and 25-desacetyl rifampicin)

• Cannabinoids in Oil Assays

  Cannabichromene (CBC) Cannabidiol (CBD) Cannabigerol (CBG)

  Cannabinol (CBN) Delta9-tetrahydrocannabinol (9-THC) Tetrahydrocannabivarin (THCV)