MTBVAC TB vaccine study commences

15 Sep 2015
MTBVac TB Study
15 Sep 2015

CAPE TOWN, SEPTEMBER 2015: On Tuesday 8 September 2015 researchers at the South African Tuberculosis Vaccine Initiative (SATVI) announced the roll out of a clinical trial to test MTBVAC TB vaccine a live-attenuated derivative of  Mycobacterium tuberculosis. The vaccine, which has been previously tested in a phase I trial  in Switzerland, is intended as a BCG replacement vaccine.

MTBVac SIV Sep 2015
Site Initiation visit, Worcester September 2015. 

.According to Dr Michele Tameris, the Principal Investigator from SATVI, the study would commence mid September  2015 and will be conducted over a two year period where after the research findings will be published.

What is the MTBVac?

What is MTBVAC


Citation: Martín C, Marinova D, Aguiló N, Gonzalo-Asensio J. MTBVAC, a live TB vaccine poised to initiate efficacy trials 100 years after BCG. Vaccine. 2021 Dec 8;39(50):7277-7285. 

MTBVAC Diagram


Rational for this study: Tuberculosis remains a major global health problem and is responsible for infecting a third of the world’s population. In 2011 there were 8.7 million new cases of TB worldwide and 1.4 million people died from the disease. The only licensed TB vaccine is BCG which is over 90 years old. Although it protects against severe forms of paediatric disease BCG is of little or no protection against adult  lung TB, the main source of transmission of the epidemic.